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Targeting Progression in Pulmonary Fibrosis: An Overview of Underlying Mechanisms, Molecular Biomarkers, and Therapeutic Intervention.
D'Agnano, Vito; Mariniello, Domenica Francesca; Ruotolo, Michela; Quarcio, Gianluca; Moriello, Alessandro; Conte, Stefano; Sorrentino, Antonio; Sanduzzi Zamparelli, Stefano; Bianco, Andrea; Perrotta, Fabio.
Afiliación
  • D'Agnano V; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Mariniello DF; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Ruotolo M; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Quarcio G; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Moriello A; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Conte S; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Sorrentino A; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Sanduzzi Zamparelli S; Division of Pneumology, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Bianco A; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
  • Perrotta F; Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Life (Basel) ; 14(2)2024 Feb 06.
Article en En | MEDLINE | ID: mdl-38398739
ABSTRACT
Interstitial lung diseases comprise a heterogenous range of diffuse lung disorders, potentially resulting in pulmonary fibrosis. While idiopathic pulmonary fibrosis has been recognized as the paradigm of a progressive fibrosing interstitial lung disease, other conditions with a progressive fibrosing phenotype characterized by a significant deterioration of the lung function may lead to a burden of significant symptoms, a reduced quality of life, and increased mortality, despite treatment. There is now evidence indicating that some common underlying biological mechanisms can be shared among different chronic fibrosing disorders; therefore, different biomarkers for disease-activity monitoring and prognostic assessment are under evaluation. Thus, understanding the common pathways that induce the progression of pulmonary fibrosis, comprehending the diversity of these diseases, and identifying new molecular markers and potential therapeutic targets remain highly crucial assignments. The purpose of this review is to examine the main pathological mechanisms regulating the progression of fibrosis in interstitial lung diseases and to provide an overview of potential biomarker and therapeutic options for patients with progressive pulmonary fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza