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Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes.
Campagna, Roberto; Serritelli, Emma Nicol; Salvolini, Eleonora; Schiavoni, Valentina; Cecati, Monia; Sartini, Davide; Pozzi, Valentina; Emanuelli, Monica.
Afiliación
  • Campagna R; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Serritelli EN; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Salvolini E; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Schiavoni V; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Cecati M; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Sartini D; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Pozzi V; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
  • Emanuelli M; Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Biomolecules ; 14(2)2024 Feb 09.
Article en En | MEDLINE | ID: mdl-38397445
ABSTRACT
Paraoxonase-2 (PON2) is a ubiquitously expressed intracellular protein that is localized in the perinuclear region, the endoplasmic reticulum (ER), and mitochondria, and is also associated with the plasma membrane. PON2 functions as an antioxidant enzyme by reducing the levels of reactive oxygen species (ROS) in the mitochondria and ER through different mechanisms, thus having an anti-apoptotic effect and preventing the formation of atherosclerotic lesions. While the antiatherogenic role played by this enzyme has been extensively explored within endothelial cells in association with vascular disorders, in the last decade, great efforts have been made to clarify its potential involvement in both blood and solid tumors, where PON2 was reported to be overexpressed. This review aims to deeply and carefully examine the contribution of this enzyme to different aspects of tumor cells by promoting the initiation, progression, and spread of neoplasms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Neoplasias Límite: Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Neoplasias Límite: Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza