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Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1ß Inflammatory Biomarkers in Old Individuals and Mice.
Marcos-Pérez, Diego; Cruces-Salguero, Sara; García-Domínguez, Esther; Araúzo-Bravo, Marcos J; Gómez-Cabrera, Mari Carmen; Viña, José; Vergara, Itziar; Matheu, Ander.
Afiliación
  • Marcos-Pérez D; Cellular Oncology Group, Biogipuzkoa Health Research Institute, 20014 San Sebastián, Spain.
  • Cruces-Salguero S; Cellular Oncology Group, Biogipuzkoa Health Research Institute, 20014 San Sebastián, Spain.
  • García-Domínguez E; Freshage Research Group, Faculty of Medicine, Fundación Investigación Hospital Clínico Universitario/Health Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain.
  • Araúzo-Bravo MJ; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERfes), 28029 Madrid, Spain.
  • Gómez-Cabrera MC; Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014 San Sebastián, Spain.
  • Viña J; IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain.
  • Vergara I; Freshage Research Group, Faculty of Medicine, Fundación Investigación Hospital Clínico Universitario/Health Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain.
  • Matheu A; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERfes), 28029 Madrid, Spain.
Biomolecules ; 14(2)2024 Jan 31.
Article en En | MEDLINE | ID: mdl-38397403
ABSTRACT

BACKGROUND:

Frailty is a geriatric syndrome associated with negative health outcomes that represents a dynamic condition with a potential of reversibility after physical exercise interventions. Typically, inflammatory and senescence markers are increased in frail individuals. However, the impact that physical exercise exerts on inflammatory and senescence biomarkers remains unknown. We assessed the effect of physical intervention in old individuals and mice and determined the expression of inflammatory and senescence markers.

METHODS:

Twelve elderly individuals were enrolled from a primary care setting to a 3-month intervention. Frailty was measured by SPPB and the expression of biomarkers by cytokine array and RT-qPCR. In addition, 12 aged C57BL/6 mice completed an intervention, and inflammation and senescence markers were studied.

RESULTS:

The physical intervention improved the SPPB score, reducing frail and pre-frail individuals. This was correlated with a reduction in several pro-inflammatory biomarkers such as IL-6, CXCL-1, CXCL-10, IL-1ß, IL-7, GM-CSF as well as p16INK4a and p21CIP1 senescence markers. Otherwise, the levels of anti-inflammatory biomarker IL-4 were significantly increased. Moreover, the physical intervention in mice also improved their functional capacity and restored the expression of inflammatory (Il-1ß, Cxcl-10, Il-6, and Cxcl-1) and senescence (p21Cip1) markers. Additionally, PLSDA and ROC curve analysis revealed CXCL-10 and IL-1ß to be the biomarkers of functional improvement in both cohorts.

CONCLUSIONS:

Our results showed that a physical intervention improves physical frailty, and reverses inflammation and senescence biomarkers comprising CXCL-10 and IL-1ß.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad Límite: Aged / Animals / Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad Límite: Aged / Animals / Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza