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Antioxidants in Photoaging: From Molecular Insights to Clinical Applications.
Calvo, María José; Navarro, Carolina; Durán, Pablo; Galan-Freyle, Nataly J; Parra Hernández, Luis Alberto; Pacheco-Londoño, Leonardo C; Castelanich, Desiree; Bermúdez, Valmore; Chacin, Maricarmen.
Afiliación
  • Calvo MJ; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela.
  • Navarro C; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela.
  • Durán P; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela.
  • Galan-Freyle NJ; Centro de Investigaciones en Ciencias de la Vida (CICV), Universidad Simón Bolívar, Barranquilla 080003, Colombia.
  • Parra Hernández LA; International Society for Non-Surgical Facial Rejuvenation (SIRF), Barranquilla 080003, Colombia.
  • Pacheco-Londoño LC; Centro de Investigaciones en Ciencias de la Vida (CICV), Universidad Simón Bolívar, Barranquilla 080003, Colombia.
  • Castelanich D; International Society for Non-Surgical Facial Rejuvenation (SIRF), Barranquilla 080003, Colombia.
  • Bermúdez V; Argentine Society of Dermatology, Buenos Aires B1228, Argentina.
  • Chacin M; Centro de Investigaciones en Ciencias de la Vida (CICV), Universidad Simón Bolívar, Barranquilla 080003, Colombia.
Int J Mol Sci ; 25(4)2024 Feb 18.
Article en En | MEDLINE | ID: mdl-38397077
ABSTRACT
Photoaging (PA) is considered a silent disease affecting millions of people globally and is defined as skin damage due to prolonged exposure to ultraviolet radiation (UVR) from the sun. Physiologically, the skin is in a state of renewal and synthesis of components of the extracellular matrix (ECM). However, exposure to UVR affects the production of the ECM, and the functioning and response of skin cells to UVR begins to change, thus expressing clinical and phenotypic characteristics of PA. The primary mechanisms involved in PA are direct damage to the DNA of skin cells, increases in oxidative stress, the activation of cell signaling pathways responsible for the loss of skin integrity, and cytotoxicity. The medical and scientific community has been researching new therapeutic tools that counteract PA, considering that the damage caused by UVR exceeds the antioxidant defense mechanisms of the skin. Thus, in recent years, certain nutraceuticals and phytochemicals have been found to exhibit potential antioxidant and photoprotective effects. Therefore, the main objective of this review is to elucidate the molecular bases of PA and the latest pharmaceutical industry findings on antioxidant treatment against the progression of PA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Antioxidantes Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Venezuela Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Antioxidantes Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Venezuela Pais de publicación: Suiza