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Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.
Sias, Ana C; Jafar, Yousif; Goodpaster, Caitlin M; Ramírez-Armenta, Kathia; Wrenn, Tyler M; Griffin, Nicholas K; Patel, Keshav; Lamparelli, Alexander C; Sharpe, Melissa J; Wassum, Kate M.
Afiliación
  • Sias AC; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Jafar Y; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Goodpaster CM; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ramírez-Armenta K; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Wrenn TM; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Griffin NK; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Patel K; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Lamparelli AC; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Sharpe MJ; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Wassum KM; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Neurosci ; 27(4): 728-736, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38396258
ABSTRACT
To make adaptive decisions, we build an internal model of the associative relationships in an environment and use it to make predictions and inferences about specific available outcomes. Detailed, identity-specific cue-reward memories are a core feature of such cognitive maps. Here we used fiber photometry, cell-type and pathway-specific optogenetic manipulation, Pavlovian cue-reward conditioning and decision-making tests in male and female rats, to reveal that ventral tegmental area dopamine (VTADA) projections to the basolateral amygdala (BLA) drive the encoding of identity-specific cue-reward memories. Dopamine is released in the BLA during cue-reward pairing; VTADA→BLA activity is necessary and sufficient to link the identifying features of a reward to a predictive cue but does not assign general incentive properties to the cue or mediate reinforcement. These data reveal a dopaminergic pathway for the learning that supports adaptive decision-making and help explain how VTADA neurons achieve their emerging multifaceted role in learning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo Nuclear Basolateral Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo Nuclear Basolateral Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos