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The effects of double-filtration plasmapheresis on coagulation profiles and the risk of bleeding.
Pan, Szu-Yu; Tao-Min Huang, Thomas; Lin, Yi-Chan; Liu, Hui-Ting; Chou, Sheng-Chieh; Lee, Chih-Yuan; Chen, Chien-Chia; Fu, Chuan-Hsiu; Chao, Chi-Chao; Wu, Vin-Cent.
Afiliación
  • Pan SY; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei City, Taiwan; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei City, Taiwan.
  • Tao-Min Huang T; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei City, Taiwan. Electronic address: taomin.huang@gmail.com.
  • Lin YC; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei City, Taiwan.
  • Liu HT; Department of Nursing, National Taiwan University Hospital, Taipei City, Taiwan.
  • Chou SC; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Lee CY; Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Chen CC; Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Fu CH; Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan.
  • Chao CC; Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan.
  • Wu VC; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei City, Taiwan.
J Formos Med Assoc ; 123(8): 899-903, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38395630
ABSTRACT
BACKGROUND/

PURPOSE:

Double-filtration plasmapheresis (DFPP) can be used to remove circulating pathogenic molecules. By reclaiming filtered albumin, DFPP reduces the need for albumin and plasma replacement. Large proteins, such as fibrinogen, are removed. Our institution adopts a DFPP treatment protocol consisting of active surveillance of coagulation profiles and prophylactic supplementation of blood products containing fibrinogen. This study aims to investigate the effects of consecutive DFPP treatments on serial coagulation profiles and the risk of bleeding under this protocol.

METHODS:

Serial laboratory data and bleeding events at a single tertiary medical center were prospectively collected. Prophylactic transfusion of cryoprecipitate or fresh frozen plasma (FFP) was instituted if significant coagulopathy or a clinically evident bleeding event was observed.

RESULTS:

After the first treatment session, plasma fibrinogen levels decreased from 332 ± 106 mg/dL to 96 ± 44 mg/dL in the 37 study patients. In the following sessions, plasma fibrinogen levels were maintained at around 100 mg/dL under prophylactic transfusion. No major bleeding events were recorded, but five (14%) patients experienced minor bleeding.

CONCLUSION:

DFPP treatment might be performed safely along with active monitoring of coagulation profiles and prophylactic transfusion of cryoprecipitate or FFP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrinógeno / Plasmaféresis / Hemorragia Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Formos Med Assoc Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrinógeno / Plasmaféresis / Hemorragia Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Formos Med Assoc Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur