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Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing.
Kawamura, Lorena Roberta de Souza Mendes; Sarmet, Max; de Campos, Priscila Sales; Takehara, Sachiko; Kumei, Yasuhiro; Zeredo, Jorge Luis Lopes.
Afiliación
  • Kawamura LRSM; Graduate Program in Health Sciences, University of Brasilia, Brasilia, Brazil.
  • Sarmet M; Graduate Program in Health Sciences and Technologies, University of Brasilia, Brasilia, Brazil.
  • de Campos PS; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL, USA.
  • Takehara S; Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Kumei Y; Department of Pathological Biochemistry, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Zeredo JLL; Graduate Program in Health Sciences, University of Brasilia, Brasilia, Brazil; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL, USA. Electronic address: jllzeredo@unb.br.
Respir Physiol Neurobiol ; 323: 104239, 2024 05.
Article en En | MEDLINE | ID: mdl-38395210
ABSTRACT
This study aimed to evaluate the timing and frequency of spontaneous apneas during breathing and swallowing by using cineradiography on mouse models of early/initial or late/advanced Parkinson's disease (PD). C57BL/6 J mice received either 6-OHDA or vehicle injections into their right striatum, followed by respiratory movement recordings during spontaneous breathing and swallowing, and a stress challenge, two weeks later. Experimental group animals showed a significantly lower respiratory rate (158.66 ± 32.88 breaths/minute in late PD, 173.16 ± 25.19 in early PD versus 185.27 ± 25.36 in controls; p<0.001) and a significantly higher frequency of apneas (median 1 apnea/minute in both groups versus 0 in controls; p<0.001). Other changes included reduced food intake and the absence of swallow apneas in experimental mice. 6-OHDA-induced nigrostriatal degeneration in mice disrupted respiratory control, swallowing, stress responsiveness, and feeding behaviors, potentially hindering airway protection and elevating the risk of aspiration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Apnea Límite: Animals Idioma: En Revista: Respir Physiol Neurobiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Apnea Límite: Animals Idioma: En Revista: Respir Physiol Neurobiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos