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Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health.
Yang, Guan; Gou, Dongzhi; Bu, Ling-Kang; Wei, Xing-Yi; Hu, Huan; Huo, Wen-Bo; Sultan, Marriya; Pei, De-Sheng.
Afiliación
  • Yang G; College of Architecture and Urban Planning, Chongqing Jiaotong University, Chongqing 400074, China.
  • Gou D; Chongqing Institute of Green and Intelligent Technology, Chongqing School of University of Chinese Academy of Sciences, Chinese Academy of Sciences, Chongqing 400714, China.
  • Bu LK; School of Public Health, Chongqing Medical University, Chongqing 400016, China.
  • Wei XY; School of Public Health, Chongqing Medical University, Chongqing 400016, China.
  • Hu H; Chongqing Institute of Green and Intelligent Technology, Chongqing School of University of Chinese Academy of Sciences, Chinese Academy of Sciences, Chongqing 400714, China.
  • Huo WB; School of Public Health, Chongqing Medical University, Chongqing 400016, China.
  • Sultan M; College of Architecture and Urban Planning, Chongqing Jiaotong University, Chongqing 400074, China.
  • Pei DS; Chongqing Institute of Green and Intelligent Technology, Chongqing School of University of Chinese Academy of Sciences, Chinese Academy of Sciences, Chongqing 400714, China.
Toxics ; 12(2)2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38393245
ABSTRACT
Poly(3,4-ethylenedioxythiophene)poly(styrenesulfonate) (PEDOTPSS) is a conductive polymer commonly used in various technological applications. However, its impact on aquatic ecosystems remains largely unexplored. In this study, we investigated the toxicity effects of PEDOTPSS on zebrafish. We first determined the lethal concentration (LC50) of PEDOTPSS in zebrafish and then exposed AB-type zebrafish embryos to different concentrations of PEDOTPSS for 120 h. Our investigation elucidated the toxicity effects of zebrafish development, including morphological assessments, heart rate measurements, behavioral analysis, transcriptome profiling, and histopathological analysis. We discovered that PEDOTPSS exhibited detrimental effects on the early developmental stages of zebrafish, exacerbating the oxidative stress level, suppressing zebrafish activity, impairing cardiac development, and causing intestinal cell damage. This study adds a new dimension to the developmental toxicity of PEDOTPSS in zebrafish. Our findings contribute to our understanding of the ecological repercussions of PEDOTPSS and highlight the importance of responsible development and application of novel materials in our rapidly evolving technological landscape.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxics Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxics Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza