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Venom Composition of Neglected Bothropoid Snakes from the Amazon Rainforest: Ecological and Toxinological Implications.
Freitas-de-Sousa, Luciana A; Colombini, Mônica; Souza, Vinicius C; Silva, Joanderson P C; Mota-da-Silva, Ageane; Almeida, Marllus R N; Machado, Reginaldo A; Fonseca, Wirven L; Sartim, Marco A; Sachett, Jacqueline; Serrano, Solange M T; Junqueira-de-Azevedo, Inácio L M; Grazziotin, Felipe G; Monteiro, Wuelton M; Bernarde, Paulo S; Moura-da-Silva, Ana M.
Afiliación
  • Freitas-de-Sousa LA; Laboratório de Imunopatologia, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Colombini M; Laboratório de Imunopatologia, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Souza VC; Laboratório de Toxinologia Aplicada, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Silva JPC; Laboratório de Toxinologia Aplicada, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Mota-da-Silva A; Instituto Federal do Acre, Campus de Cruzeiro do Sul, Cruzeiro do Sul 69980-000, AC, Brazil.
  • Almeida MRN; Laboratório de Herpetologia, Universidade Federal do Acre, Campus Floresta, Cruzeiro do Sul 69895-000, AC, Brazil.
  • Machado RA; Laboratório de Herpetologia, Universidade Federal do Acre, Campus Floresta, Cruzeiro do Sul 69895-000, AC, Brazil.
  • Fonseca WL; Laboratório de Herpetologia, Universidade Federal do Acre, Campus Floresta, Cruzeiro do Sul 69895-000, AC, Brazil.
  • Sartim MA; Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, AM, Brazil.
  • Sachett J; Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, AM, Brazil.
  • Serrano SMT; Laboratório de Toxinologia Aplicada, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Junqueira-de-Azevedo ILM; Laboratório de Toxinologia Aplicada, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Grazziotin FG; Laboratório de Coleções Zoológicas, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
  • Monteiro WM; Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, AM, Brazil.
  • Bernarde PS; Laboratório de Herpetologia, Universidade Federal do Acre, Campus Floresta, Cruzeiro do Sul 69895-000, AC, Brazil.
  • Moura-da-Silva AM; Laboratório de Imunopatologia, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
Toxins (Basel) ; 16(2)2024 02 04.
Article en En | MEDLINE | ID: mdl-38393161
ABSTRACT
Snake venoms have evolved in several families of Caenophidae, and their toxins have been assumed to be biochemical weapons with a role as a trophic adaptation. However, it remains unclear how venom contributes to the success of venomous species for adaptation to different environments. Here we compared the venoms from Bothrocophias hyoprora, Bothrops taeniatus, Bothrops bilineatus smaragdinus, Bothrops brazili, and Bothrops atrox collected in the Amazon Rainforest, aiming to understand the ecological and toxinological consequences of venom composition. Transcriptomic and proteomic analyses indicated that the venoms presented the same toxin groups characteristic from bothropoids, but with distinct isoforms with variable qualitative and quantitative abundances, contributing to distinct enzymatic and toxic effects. Despite the particularities of each venom, commercial Bothrops antivenom recognized the venom components and neutralized the lethality of all species. No clear features could be observed between venoms from arboreal and terrestrial habitats, nor in the dispersion of the species throughout the Amazon habitats, supporting the notion that venom composition may not shape the ecological or toxinological characteristics of these snake species and that other factors influence their foraging or dispersal in different ecological niches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bothrops / Venenos de Crotálidos / Serpientes Venenosas Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bothrops / Venenos de Crotálidos / Serpientes Venenosas Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza