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Modulation of Immune Response and Cecal Microbiota by Dietary Fenugreek Seeds in Broilers.
Paneru, Deependra; Tellez-Isaias, Guillermo; Bottje, Walter G; Asiamah, Emmanuel; Abdel-Wareth, Ahmed A A; Salahuddin, Md; Lohakare, Jayant.
Afiliación
  • Paneru D; Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.
  • Tellez-Isaias G; Center of Excellence in Poultry Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.
  • Bottje WG; Center of Excellence in Poultry Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.
  • Asiamah E; Department of Agriculture, University of Arkansas at Pine Bluff, Pine Bluff, AR 71601, USA.
  • Abdel-Wareth AAA; Department of Animal and Poultry Production, Faculty of Agriculture, South Valley University, Qena 83523, Egypt.
  • Salahuddin M; Poultry Center, Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX 77446, USA.
  • Lohakare J; Poultry Center, Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX 77446, USA.
Vet Sci ; 11(2)2024 Jan 28.
Article en En | MEDLINE | ID: mdl-38393075
ABSTRACT
Fenugreek seeds (FSs) are a natural source of bioactive compounds that may modulate the immune system and gut microbiota in broilers. This study examined the effects of dietary fenugreek seed powder on immune-related gene expression and cecal microbiota composition in broilers. A total of 144 broiler chickens were randomly allocated to three dietary groups, CON (0 g/kg FS, FS5 (5 g/kg FS) and FS10 (10 g/kg FS), each with 6 replicates of 8 birds. Ileum tissues and cecal contents were collected on day 42 for the mRNA expression of inflammation and antimicrobial defense-related genes and cecal microbiome diversity, respectively. The results indicated that fenugreek seeds downregulated mRNA-level inflammation and antimicrobial defense-related genes IL6, IL8L2, CASP6, PTGS2, IRF7, AvBD9, AvBD10, and AvBD11. Moreover, fenugreek seeds altered the cecal microbial community by increasing the population of Firmicutes and decreasing the population of Actinobacteriota, Gemmatimonadota and Verrucomicrobiota at the phylum level and increasing Alistipes, Bacteriodes and Prevotellaceae at the genera level. These findings suggest that fenugreek seeds have a positive impact on the immunological profile and microbiome of broiler chickens, possibly through the interplay of the immune system and the gut microbiome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza