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Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed Halimeda tuna: Computational and Experimental Evidences.
Kraiem, Marwa; Ben Hamouda, Sonia; Eleroui, Malek; Ajala, Marwa; Feki, Amal; Dghim, Amel; Boujhoud, Zakaria; Bouhamed, Marwa; Badraoui, Riadh; Pujo, Jean Marc; Essafi-Benkhadir, Khadija; Kallel, Hatem; Ben Amara, Ibtissem.
Afiliación
  • Kraiem M; Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, PB 261, Sfax 3000, Tunisia.
  • Ben Hamouda S; Laboratory of Molecular Epidemiology and Experimental Pathology-LR16IPT04, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
  • Eleroui M; Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, PB 261, Sfax 3000, Tunisia.
  • Ajala M; Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, PB 261, Sfax 3000, Tunisia.
  • Feki A; Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, PB 261, Sfax 3000, Tunisia.
  • Dghim A; Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, PB 261, Sfax 3000, Tunisia.
  • Boujhoud Z; Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences of Settat, Hassan First University of Settat, Settat 26000, Morocco.
  • Bouhamed M; Laboratory of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia.
  • Badraoui R; Department of General Biology, University of Ha'il, Ha'il 81451, Saudi Arabia.
  • Pujo JM; Section of Histology-Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, La Rabta 1007, Tunisia.
  • Essafi-Benkhadir K; Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana.
  • Kallel H; Laboratory of Molecular Epidemiology and Experimental Pathology-LR16IPT04, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
  • Ben Amara I; Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana.
Mar Drugs ; 22(2)2024 Feb 11.
Article en En | MEDLINE | ID: mdl-38393056
ABSTRACT
In this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae Halimeda tuna. PSHT exhibited anti-oxidant activity in vitro through scavenging 1, 1-diphenyl-2-picryl hydroxyl free radical, reducing Fe3+/ferricyanide complex, and inhibiting nitric oxide. PSHT maintained the erythrocyte membrane integrity and prevented hemolysis. Our results also showed that PSHT exerted a significant anti-edematic effect in vivo by decreasing advanced oxidation protein products and malondialdehyde levels and increasing the superoxide dismutase and glutathione peroxidase activities in rat's paw model and erythrocytes. Interestingly, PSHT increased the viability of murine RAW264.7 macrophages and exerted an anti-inflammatory effect on lipopolysaccharide-stimulated cells by decreasing pro-inflammatory molecule levels, including nitric oxide, granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-α). Our findings indicate that PSHT could be used as a potential immunomodulatory, anti-inflammatory, anti-hemolytic, and anti-oxidant agent. These results could be explained by the computational findings showing that polysaccharide building blocks bound both cyclooxygenase-2 (COX-2) and TNF-α with acceptable affinities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Chlorophyta Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Chlorophyta Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza