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Nerve Growth Factor and the Role of Inflammation in Tumor Development.
Ferraguti, Giampiero; Terracina, Sergio; Tarani, Luigi; Fanfarillo, Francesca; Allushi, Sara; Caronti, Brunella; Tirassa, Paola; Polimeni, Antonella; Lucarelli, Marco; Cavalcanti, Luca; Greco, Antonio; Fiore, Marco.
Afiliación
  • Ferraguti G; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Terracina S; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Tarani L; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
  • Fanfarillo F; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Allushi S; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Caronti B; Department of Human Neurosciences, Sapienza University Hospital of Rome, 00185 Rome, Italy.
  • Tirassa P; Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
  • Polimeni A; Department of Odontostomatological and Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy.
  • Lucarelli M; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Cavalcanti L; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy.
  • Greco A; Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
  • Fiore M; Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
Curr Issues Mol Biol ; 46(2): 965-989, 2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38392180
ABSTRACT
Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza