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Corrosive induced esophageal and gastric injury: Histopathological evaluation of surgically resected specimens over a decade in a tertiary care center.
Shah, Jimil; Jena, Anuraag; Shweta, Shweta; Vaiphei, Kim; Gupta, Vikas; Kumar, Naveen; Singh, Anupam K; Kochhar, Rakesh.
Afiliación
  • Shah J; Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Jena A; Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Shweta S; Department of Histopathology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Vaiphei K; Department of Histopathology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Gupta V; Department of Surgical Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Kumar N; Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Singh AK; Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Kochhar R; Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Indian J Pathol Microbiol ; 67(2): 379-384, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38391330
ABSTRACT

BACKGROUND:

Caustic ingestion is associated with long-term sequelae like esophageal stricture, gastric cicatrization, and long-term risk of dysplasia or even carcinoma. However, only a few small studies have explored histopathological aspects of caustic-induced esophageal/gastric injury. MATERIALS AND

METHODS:

We retrospectively evaluated specimens of patients undergoing surgery due to caustic ingestion-related complications from 2008 to 2020. Pathological examination was conducted by two independent gastro-pathologists to evaluate the extent and depth of the caustic injury, presence or absence of tissue necrosis, type and degree of inflammation, or presence of any dysplastic cells.

RESULTS:

A total of 54 patients underwent surgical exploration during the inclusion period and complete details of 39 specimens could be retrieved. The mean age of the included patients was 28.66 ± 9.31 years and 25 (64.1%) were male. The majority of patients (30; 76.9%) had a history of caustic ingestion more than three months before the surgery and the presence of long or refractory stricture was the most common indication for the surgery (20; 51.28%). In the resected specimen, a majority of patients had superficial esophageal or gastric ulcer (90.6%; 60.0%), transmural inflammation (68.8%; 65.6%), transmural fibrosis (62.5%; 34.4%), and hypertrophied muscularis mucosa (78.13%; 53.3%). However, none of the patients had dysplasia in the resected esophageal or gastric specimens.

CONCLUSION:

Caustic ingestion leads to mucosal ulceration, transmural inflammation, and transmural fibrosis which might be the reason for refractory stricture in such patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estómago / Quemaduras Químicas / Cáusticos / Esófago / Centros de Atención Terciaria Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Indian J Pathol Microbiol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estómago / Quemaduras Químicas / Cáusticos / Esófago / Centros de Atención Terciaria Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Indian J Pathol Microbiol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: India