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(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.
Yokoyama, Rei; Ago, Yukio; Igarashi, Hisato; Higuchi, Momoko; Tanuma, Masato; Shimazaki, Yuto; Kawai, Takafumi; Seiriki, Kaoru; Hayashida, Misuzu; Yamaguchi, Shun; Tanaka, Hirokazu; Nakazawa, Takanobu; Okamura, Yasushi; Hashimoto, Kenji; Kasai, Atsushi; Hashimoto, Hitoshi.
Afiliación
  • Yokoyama R; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Ago Y; Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, 734-8553, Japan.
  • Igarashi H; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Higuchi M; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Tanuma M; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Shimazaki Y; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Kawai T; Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Seiriki K; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Hayashida M; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Yamaguchi S; Department of Morphological Neuroscience, Graduate School of Medicine, Gifu University, Gifu, Gifu, 501-1194, Japan.
  • Tanaka H; Center for One Medicine Innovative Translational Research, Institute for Advanced Study, Gifu University, Gifu, Gifu, 501-1194, Japan.
  • Nakazawa T; Faculty of Information Technology, Tokyo City University, Setagaya, Tokyo, 158-8557, Japan.
  • Okamura Y; Department of Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan.
  • Hashimoto K; Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Kasai A; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565-0871, Japan.
  • Hashimoto H; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chuo, Chiba, 260-8670, Japan.
Mol Psychiatry ; 29(5): 1406-1416, 2024 May.
Article en En | MEDLINE | ID: mdl-38388704
ABSTRACT
Chronic social isolation increases the risk of mental health problems, including cognitive impairments and depression. While subanesthetic ketamine is considered effective for cognitive impairments in patients with depression, the neural mechanisms underlying its effects are not well understood. Here we identified unique activation of the anterior insular cortex (aIC) as a characteristic feature in brain-wide regions of mice reared in social isolation and treated with (R)-ketamine, a ketamine enantiomer. Using fiber photometry recording on freely moving mice, we found that social isolation attenuates aIC neuronal activation upon social contact and that (R)-ketamine, but not (S)-ketamine, is able to counteracts this reduction. (R)-ketamine facilitated social cognition in social isolation-reared mice during the social memory test. aIC inactivation offset the effect of (R)-ketamine on social memory. Our results suggest that (R)-ketamine has promising potential as an effective intervention for social cognitive deficits by restoring aIC function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aislamiento Social / Disfunción Cognitiva / Corteza Insular / Ketamina Límite: Animals Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aislamiento Social / Disfunción Cognitiva / Corteza Insular / Ketamina Límite: Animals Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido