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Driving Hebbian plasticity over ventral premotor-motor projections transiently enhances motor resonance.
Chiappini, Emilio; Turrini, Sonia; Zanon, Marco; Marangon, Mattia; Borgomaneri, Sara; Avenanti, Alessio.
Afiliación
  • Chiappini E; Department of Clinical and Health Psychology, University of Vienna, 1010, Vienna, Austria; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Department of Psychology an
  • Turrini S; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Massachusetts General Hospita
  • Zanon M; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Neuroscience Area, International School for Advanced Studies (SISSA), 34136, Trieste, Italy.
  • Marangon M; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Dipartimento di Neuroscienze, Biomedicina e Scienze del Movimento, Sezione di Fisiologia e Psicologia, Università di V
  • Borgomaneri S; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy.
  • Avenanti A; Centro Studi e Ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari", Campus di Cesena, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Centro de Investigación en Neuropsicología y Neurociencias Cognitivas (CINPSI Neurocog), Universidad Católica Del Maul
Brain Stimul ; 17(2): 211-220, 2024.
Article en En | MEDLINE | ID: mdl-38387557
ABSTRACT

BACKGROUND:

Making sense of others' actions relies on the activation of an action observation network (AON), which maps visual information about observed actions onto the observer's motor system. This motor resonance process manifests in the primary motor cortex (M1) as increased corticospinal excitability finely tuned to the muscles engaged in the observed action. Motor resonance in M1 is facilitated by projections from higher-order AON regions. However, whether manipulating the strength of AON-to-M1 connectivity affects motor resonance remains unclear.

METHODS:

We used transcranial magnetic stimulation (TMS) in 48 healthy humans. Cortico-cortical paired associative stimulation (ccPAS) was administered over M1 and the ventral premotor cortex (PMv), a key AON node, to induce spike-timing-dependent plasticity (STDP) in the pathway connecting them. Single-pulse TMS assessed motor resonance during action observation.

RESULTS:

Before ccPAS, action observation increased corticospinal excitability in the muscles corresponding to the observed movements, reflecting motor resonance in M1. Notably, ccPAS aimed at strengthening projections from PMv to M1 (PMv→M1) induced short-term enhancement of motor resonance. The enhancement specifically occurred with the ccPAS configuration consistent with forward PMv→M1 projections and dissipated 20 min post-stimulation; ccPAS administered in the reverse order (M1→PMv) and sham stimulation did not affect motor resonance.

CONCLUSIONS:

These findings provide the first evidence that inducing STDP to strengthen PMv input to M1 neurons causally enhances muscle-specific motor resonance in M1. Our study sheds light on the plastic mechanisms that shape AON functionality and demonstrates that exogenous manipulation of AON connectivity can influence basic mirror mechanisms that underlie social perception.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales Evocados Motores / Estimulación Magnética Transcraneal / Corteza Motora / Plasticidad Neuronal Límite: Adult / Female / Humans / Male Idioma: En Revista: Brain Stimul Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales Evocados Motores / Estimulación Magnética Transcraneal / Corteza Motora / Plasticidad Neuronal Límite: Adult / Female / Humans / Male Idioma: En Revista: Brain Stimul Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos