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A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms.
Liu, Congyan; Su, Wenting; Jiang, Xi; Lv, Yanli; Kong, Fei; Chen, Qin; Zhang, Qun; Zhang, Huangqin; Liu, Yuping; Li, Xiaoqi; Xu, Xinrong; Chen, Yan; Qu, Ding.
Afiliación
  • Liu C; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Su W; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Jiang X; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Lv Y; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Kong F; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Chen Q; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Zhang Q; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Zhang H; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Liu Y; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Li X; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Xu X; Department of Ophthalmology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, P. R. China.
  • Chen Y; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
  • Qu D; Jiangsu Provincial Academy of Traditional Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
Adv Healthc Mater ; 13(14): e2303659, 2024 06.
Article en En | MEDLINE | ID: mdl-38386849
ABSTRACT
Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age-related macular degeneration (wAMD). Here, a microemulsion-doped hydrogel (Bor/PT-M@TRG) is engineered as an intravitreal depot composing of temperature-responsive hydrogel (TRG) and borneol-decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)-coloaded microemulsions (Bor/PT-M). Bor/PT-M@TRG, functioning as the "ammunition depot", resides in the vitreous and continuously releases Bor/PT-M as the therapeutic "bullet", enabling deep penetration into the retina for 21 days. A single intravitreal injection of Bor/PT-M@TRG yields substantial reductions in choroidal neovascularization (CNV, a hallmark feature of wAMD) progression and mitigates oxidative stress-induced damage in vivo. Combinational PF&TMP regulates the "reactive oxygen species/nuclear factor erythroid-2-related factor 2/heme oxygenase-1" pathway and blocks the "hypoxia inducible factor-1α/vascular endothelial growth factor" signaling in retina, synergistically cutting off the loop of CNV formation. Utilizing fluorescence resonance energy transfer and liquid chromatography-mass spectrometry techniques, they present compelling multifaceted evidence of sustainable retinal codelivery spanning formulations, ARPE-19 cells, in vivo eye balls, and ex vivo section/retina-choroid complex cell levels. Such codelivery approach is elucidated as the key driving force behind the exceptional therapeutic outcomes of Bor/PT-M@TRG. These findings highlight the significance of sustainable retinal drug codelivery and rational combination for effective treatment of wAMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas Límite: Animals / Humans Idioma: En Revista: Adv Healthc Mater Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas Límite: Animals / Humans Idioma: En Revista: Adv Healthc Mater Año: 2024 Tipo del documento: Article Pais de publicación: Alemania