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Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-19 Pandemic: A Case Series.
Özdemir Yalçinsoy, Kübra; Güngör, Anil; Karakaya, Deniz; Özdal, Levent; Kiliç, Meltem; Özdamar Erol, Yasemin; Çakar Özdal, Pinar.
Afiliación
  • Özdemir Yalçinsoy K; University of Health Sciences Türkiye, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
  • Güngör A; University of Health Sciences Türkiye, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
  • Karakaya D; University of Health Sciences Türkiye, Ankara Dr. Sami Ulus Child Health and Diseases Training and Research Hospital, Clinic of Pediatric Nephrology, Ankara, Türkiye.
  • Özdal L; University of Health Sciences Türkiye, Ankara City Hospital, Clinic of Urology, Ankara, Türkiye.
  • Kiliç M; University of Health Sciences Türkiye, Ankara City Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
  • Özdamar Erol Y; University of Health Sciences Türkiye, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
  • Çakar Özdal P; University of Health Sciences Türkiye, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
Turk J Ophthalmol ; 54(1): 5-10, 2024 Feb 22.
Article en En | MEDLINE | ID: mdl-38385308
ABSTRACT

Objectives:

To report the ocular findings, laboratory results, and management of patients with tubulointerstitial nephritis and uveitis syndrome (TINU), whose numbers increased during the 2019 coronavirus disease (COVID-19) pandemic. Materials and

Methods:

Demographic characteristics, ophthalmic examination findings, laboratory results including polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), serum SARS-CoV-2 immunoglobulin G (IgG) antibody, and treatment of patients diagnosed with TINU between March 2020 and March 2022 were evaluated retrospectively.

Results:

The study included 19 eyes of 10 patients (6 female/4 male). The mean age was 13.5±2.4 years (range 8-16 years). The mean follow-up duration was 13.5±6.1 months (range 6-24 months). All patients presented with anterior uveitis. Anterior uveitis was bilateral in 9 patients (90%) and unilateral in 1 patient (10%). Posterior segment findings were normal in 8 patients (80%), and bilateral optic disc edema was observed in only 2 patients (20%). None of the patients had a previous SARS-CoV-2 infection and/or vaccination history. The SARS-CoV-2 PCR test was negative in all patients at presentation. The SARS-CoV-2 IgG antibody test was reactive in 7 patients (70%). Recurrent uveitis developed in 8 patients (80%) during follow-up. Systemic immunomodulatory therapy was required for the control of ocular inflammation in 7 patients (70%) with severe uveitis flare-ups.

Conclusion:

TINU is a multisystemic autoimmune disease, especially in response to environmental triggering factors such as viral infections. Although TINU is a rare disease, the number of cases increased during the COVID-19 pandemic. SARS-CoV-2 antibodies were detected at a significant rate of 70% in these patients, who did not have a history of SARS-CoV-2 infection and vaccination. Previous asymptomatic SARS-CoV-2 infection in children may be a triggering factor in the development of TINU.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Uveítis Anterior / COVID-19 / Nefritis Intersticial Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Turk J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Uveítis Anterior / COVID-19 / Nefritis Intersticial Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Turk J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Turquía