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Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care.
Bayoumy, Ahmed B; Mulder, Chris J J; Ansari, Azhar R; Barclay, Murray L; Florin, Tim; Kiszka-Kanowitz, Marianne; Derijks, Luc; Sharma, Vishal; de Boer, Nanne K H.
Afiliación
  • Bayoumy AB; Department of Internal Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Mulder CJJ; Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. cjmdl1@gmail.com.
  • Ansari AR; Department of Gastroenterology and Hepatology, London Bridge Hospital, London, UK.
  • Barclay ML; Department of Gastroenterology, Christchurch Hospital, Christchurch, Waitaha - Canterbury, New Zealand.
  • Florin T; Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, Waitaha - Canterbury, New Zealand.
  • Kiszka-Kanowitz M; Mater Research, University of Queensland, Translational Research Institute, South Brisbane, Australia.
  • Derijks L; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre Hospital, Hvidovre, Denmark.
  • Sharma V; Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, The Netherlands.
  • de Boer NKH; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, The Netherlands.
Indian J Gastroenterol ; 43(1): 36-47, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38383877
ABSTRACT
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses two major conditions Crohn's disease (CD) and ulcerative colitis (UC). Historically, IBD has been primarily reported in western countries, but over the past decades, its prevalence is rapidly increasing, especially in lower and middle-income countries (LMICs) such as India and China and also in Sub-Saharan Africa. The prevalence of IBD in LMICs has been the subject of growing concern due to the impact of access to public healthcare and the burden it places on healthcare resources. The classical thiopurines face significant challenges due to cessation of therapy in approximately half of patients within one year due to side effects or ineffectiveness. In this article, we highlight innovating thiopurine treatment for IBD patients in downregulating side effects and improving efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Compuestos de Sulfhidrilo / Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa / Enfermedad de Crohn Límite: Humans Idioma: En Revista: Indian J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Compuestos de Sulfhidrilo / Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa / Enfermedad de Crohn Límite: Humans Idioma: En Revista: Indian J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: India