Your browser doesn't support javascript.
loading
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies.
Ferrari, Mathieu; Righi, Matteo; Baldan, Vania; Wawrzyniecka, Patrycja; Bulek, Anna; Kinna, Alexander; Ma, Biao; Bughda, Reyisa; Akbar, Zulaikha; Srivastava, Saket; Gannon, Isaac; Robson, Mathew; Sillibourne, James; Jha, Ram; El-Kholy, Mohamed; Amin, Oliver Muhammad; Kokalaki, Evangelia; Banani, Mohammed Amin; Hussain, Rehan; Day, William; Lim, Wen Chean; Ghongane, Priyanka; Hopkins, Jade R; Jungherz, Dennis; Herling, Marco; Welin, Martin; Surade, Sachin; Dyson, Michael; McCafferty, John; Logan, Derek; Cordoba, Shaun; Thomas, Simon; Sewell, Andrew; Maciocia, Paul; Onuoha, Shimobi; Pule, Martin.
Afiliación
  • Ferrari M; Autolus Therapeutics, London, UK.
  • Righi M; Autolus Therapeutics, London, UK.
  • Baldan V; Autolus Therapeutics, London, UK.
  • Wawrzyniecka P; Cardiff University School of Medicine; Heath Park, Cardiff, UK.
  • Bulek A; Autolus Therapeutics, London, UK.
  • Kinna A; Autolus Therapeutics, London, UK.
  • Ma B; Autolus Therapeutics, London, UK.
  • Bughda R; Autolus Therapeutics, London, UK.
  • Akbar Z; Autolus Therapeutics, London, UK.
  • Srivastava S; Autolus Therapeutics, London, UK.
  • Gannon I; Autolus Therapeutics, London, UK.
  • Robson M; Autolus Therapeutics, London, UK.
  • Sillibourne J; Autolus Therapeutics, London, UK.
  • Jha R; Autolus Therapeutics, London, UK.
  • El-Kholy M; Autolus Therapeutics, London, UK.
  • Amin OM; Autolus Therapeutics, London, UK.
  • Kokalaki E; Autolus Therapeutics, London, UK.
  • Banani MA; Autolus Therapeutics, London, UK.
  • Hussain R; Autolus Therapeutics, London, UK.
  • Day W; Autolus Therapeutics, London, UK.
  • Lim WC; Autolus Therapeutics, London, UK.
  • Ghongane P; Autolus Therapeutics, London, UK.
  • Hopkins JR; Cardiff University School of Medicine; Heath Park, Cardiff, UK.
  • Jungherz D; Department of Hematology, Cell Therapy, Hemostaseology, and Infectious Diseases, University of Leipzig Medical Centre, Leipzig, Germany.
  • Herling M; Department of Hematology, Cell Therapy, Hemostaseology, and Infectious Diseases, University of Leipzig Medical Centre, Leipzig, Germany.
  • Welin M; Saromics Inc., Lund, Sweden.
  • Surade S; Iontas Ltd., Pampisford, Cambridge, UK.
  • Dyson M; Iontas Ltd., Pampisford, Cambridge, UK.
  • McCafferty J; Iontas Ltd., Pampisford, Cambridge, UK.
  • Logan D; Saromics Inc., Lund, Sweden.
  • Cordoba S; Autolus Therapeutics, London, UK.
  • Thomas S; Autolus Therapeutics, London, UK.
  • Sewell A; Cardiff University School of Medicine; Heath Park, Cardiff, UK.
  • Maciocia P; Cancer Institute; University College London, London, UK.
  • Onuoha S; Autolus Therapeutics, London, UK.
  • Pule M; Autolus Therapeutics, London, UK. m.pule@ucl.ac.uk.
Nat Commun ; 15(1): 1583, 2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38383515
ABSTRACT
Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. The T cell receptor expresses one of two highly homologous chains [T cell receptor ß-chain constant (TRBC) domains 1 and 2] in a mutually exclusive manner, making it a promising target. Here we demonstrate specificity redirection by rational design using structure-guided computational biology to generate a TRBC2-specific antibody (KFN), complementing the antibody previously described by our laboratory with unique TRBC1 specificity (Jovi-1) in targeting broader spectrum of T cell malignancies clonally expressing either of the two chains. This permits generation of paired reagents (chimeric antigen receptor-T cells) specific for TRBC1 and TRBC2, with preclinical evidence to support their efficacy in T cell malignancies.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Neoplasias Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Neoplasias Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido