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lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.
Weng, Yin-Hua; Chen, Jie; Yu, Wen-Tao; Luo, Yan-Ping; Liu, Chao; Yang, Jun; Liu, Hong-Bo.
Afiliación
  • Weng YH; Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
  • Chen J; School of Clinical Medicine, Guilin Medical University, Guilin, China.
  • Yu WT; College of Medical Laboratory Science, Guilin Medical University, Guilin, China.
  • Luo YP; Department of Laboratory Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
  • Liu C; School of Clinical Medicine, Guilin Medical University, Guilin, China.
  • Yang J; School of Clinical Medicine, Guilin Medical University, Guilin, China.
  • Liu HB; Department of Laboratory Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
BMC Med Genomics ; 17(1): 58, 2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38383415
ABSTRACT

BACKGROUND:

Ischemic stroke (IS) is a common and serious neurological condition that is highly fatal but so far no early diagnostic markers are available. Myocardial infarction-associated transcript (MIAT) is a long non-coding RNA (lncRNA) that could lead to IS by inducing autophagy and apoptosis in neuronal cells. However, there has been no report on the link between susceptibility to IS and the single-nucleotide polymorphisms (SNPs) of MIAT. This study aimed to investigate the association between MIAT gene polymorphisms and IS risk.

METHODS:

A total of 320 IS patients and 310 age-, sex- and race-matched controls were included in this study. Four polymorphisms (rs2157598, rs5761664, rs1894720, and rs9625066) were genotyped by using SNPscan technique.

RESULTS:

Among the 4 polymorphisms of MIAT, only rs9625066 was associated with IS risk (CA vs. CC adjusted OR = 0.55, 95% CI, 0.37-0.85, P = 0.006; AA vs. CC adjusted OR = 0.39, 95% CI, 0.16-0.94, P = 0.036; (AA + CA vs. CC adjusted OR = 0.53, 95% CI, 0.35-0.80, P = 0.002; A vs. C adjusted OR = 0.59, 95% CI, 0.42-0.82, P = 0.002). Haplotype analysis showed a 1.32-fold increase (95% CI, 1.05-1.67, P = 0.017) in IS risk for rs2157598-rs5761664-rs1894720-rs9625066 (A-C-G-C). Logistic regression analysis identified some independent impact factors for IS including rs9625066 AA/AC, TC, TG, HDL-C (P < 0.05).

CONCLUSION:

The rs9625066 polymorphism of MIAT might be associated with IS susceptibility in Chinese population, in which AA/CA plays a protective role in IS, whereas the CC genotype increases the risk of developing IS, suggesting it might be a marker predictive of IS risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / ARN Largo no Codificante / Accidente Cerebrovascular Isquémico / Infarto del Miocardio Límite: Humans Idioma: En Revista: BMC Med Genomics Asunto de la revista: GENETICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / ARN Largo no Codificante / Accidente Cerebrovascular Isquémico / Infarto del Miocardio Límite: Humans Idioma: En Revista: BMC Med Genomics Asunto de la revista: GENETICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido