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Different profiles of chemokines, cytokines and cell growth factors in plasma samples from patients with leprosy, leprosy reactions and households contacts.
de Carvalho, Jairo Campos; Pascoal-Xavier, Marcelo Antônio; Araújo, Marcelo Grossi; Teixeira-Carvalho, Andrea; Martins-Filho, Olindo Assis; Peruhype-Magalhães, Vanessa; Coelho-Dos-Reis, Jordana Grazziela Alves; Araújo, Márcio Sobreira Silva.
Afiliación
  • de Carvalho JC; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brasil.
  • Pascoal-Xavier MA; Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, MG, Brasil.
  • Araújo MG; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brasil.
  • Teixeira-Carvalho A; Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Anatomia Patológica e Medicina Legal, Belo Horizonte, MG, Brasil.
  • Martins-Filho OA; Serviço de Dermatologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
  • Peruhype-Magalhães V; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brasil.
  • Coelho-Dos-Reis JGA; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brasil.
  • Araújo MSS; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brasil.
Mem Inst Oswaldo Cruz ; 119: e230129, 2024.
Article en En | MEDLINE | ID: mdl-38381878
ABSTRACT

BACKGROUND:

Leprosy is a highly neglected disease that is considered a serious public health problem in many countries. This illness is characterised by a variety of clinical and histopathological manifestations that are related to the patient immune response.

OBJECTIVES:

This work aimed evaluate the profile of circulating immune mediators in the plasma from patients classified clinically as paucibacillary (PB), multibacillary (MB), households contacts (HHC), type1 leprosy reaction (T1R), type2 leprosy reaction (T2R) and control individuals without medical history of leprosy (CTL).

METHODS:

To assessment of the plasma immune mediators was used multiplex microbeads immunoassay "Luminex".

FINDINGS:

The results showed that patients (PB) had a regulatory-biased profile, while MB revealed a pro-inflammatory trend of highly expressed biomarkers. HHC display conspicuously increased levels in the plasma of the chemokines (CCL2, CCL3, CCL4, CCL5 and CXCL8), pro-inflammatory cytokines (IFN-γ,TNF and IL-1ß), modulating cytokines (IL-9 and IL-1Ra) and growth factors (PDGF, G-CSF and IL-2). Interestingly, HHC displayed superior production of IFN-γ as compared to other leprosy groups, indicating a putative protective role for this cytokine during chronic Mycobacterium leprae exposure. MAIN

CONCLUSION:

Further investigations are currently underway to elucidate the potential of these mediators as biomarkers applicable to the diagnosis/prognosis of leprosy and also T1R and T2R leprosy reactions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Lepra Límite: Humans Idioma: En Revista: Mem Inst Oswaldo Cruz Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Lepra Límite: Humans Idioma: En Revista: Mem Inst Oswaldo Cruz Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil