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CRP/HDL-C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus.
Djesevic, Miralem; Hasic, Sabaheta; Lepara, Orhan; Jahic, Rijad; Kurtovic, Avdo; Fajkic, Almir.
Afiliación
  • Djesevic M; Department of Cardiology, Private Policlinic Center Eurofarm Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Hasic S; Department of Medical Biochemistry, Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina.
  • Lepara O; Department of Physiology, Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina.
  • Jahic R; General Hospital "Prim. Dr. Abdulah Nakas" Sarajevo, Bosnia and Herzegovina.
  • Kurtovic A; Clinical Center, University of Tuzla, Bosnia and Herzegovina.
  • Fajkic A; Department of Pathophysiology, Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina.
Acta Inform Med ; 31(4): 254-259, 2023.
Article en En | MEDLINE | ID: mdl-38379696
ABSTRACT

Background:

Metabolic syndrome (MetS) denotes a cluster of co-occurring medical conditions associated with regulating hyperglycemia and acute cardiovascular events and complications. The escalating frequency of MetS among individuals afflicted with type 2 diabetes mellitus (T2DM) underscores its burgeoning significance as a critical public health concern and a complex clinical conundrum. Timely identification is imperative to avert the expedited progression of diabetic complications.

Objective:

To investigate the role of CRP/HDL-C and Monocyte/HDL ratios in predicting MetS in T2DM individuals.

Methods:

The study was designed as a two-year prospective study and included 80 T2DM patients divided into MetS and non-MetS groups based on MetS development over two years. The patients' serums were analyzed for complete blood count parameters, lipid profile, and C-reactive protein (CRP). Based on the laboratory test results, Monocyte/HDL-C and CRP/HDL-C ratios were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy.

Results:

Monocyte/HDL-C ratio and CRP/HDL-C ratio were significantly higher in MetS-T2DM2 than in nonMetS-T2DM (p=0.003 and p=0.029, respectively). The results of ROC curve analysis have shown that the CRP/HDL-C ratio (AUC of 0.695) and Monocytes/HDL-C ratio (AUC of 0.645) can serve as good predictors of MetS in T2DM patients.

Conclusion:

This study confirms the reliability of the Monocytes/HDL-C and CRP/HDL-C ratios as novel, simple, low-cost, and valuable predictors of MetS development in T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Inform Med Año: 2023 Tipo del documento: Article Pais de publicación: Bosnia-Herzegovina
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Inform Med Año: 2023 Tipo del documento: Article Pais de publicación: Bosnia-Herzegovina