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Four unreported aporphine alkaloids with antifungal activities from Artabotrys hexapetalus.
Zhao, Pei; Yu, Zhiyin; Huang, Jian-Ping; Wang, Li; Huang, Sheng-Xiong; Yang, Jing.
Afiliación
  • Zhao P; College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China; Yinchuan Hospital of Traditional Chinese Medicine, Yinch
  • Yu Z; College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Huang JP; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
  • Wang L; College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Huang SX; College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China. Electronic address: sxhuang@mail.kib.ac.cn.
  • Yang J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China. Electronic address: yangjingc@mail.kib.ac.cn.
Fitoterapia ; 174: 105868, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38378133
ABSTRACT
In this study, the extract from Artabotrys hexapetalus showed strong antifungal activity against phytopathogenic fungi in vitro. Four unreported aporphine alkaloids, hexapetalusine A-D (1-4), were isolated from stems and roots of Artabotrys hexapetalus (L.f.) Bhandari, along with six known aporphine alkaloids (5-10). Their chemical structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-3 were determined using single-crystal X-ray diffractions and ECD calculations. Hexapetalusine A-C (1-3) were special amidic isomers. Additionally, all isolated compounds were evaluated for their antifungal activity against four phytopathogenic fungi in vitro. Hexapetalusine D (4) exhibited weak antifungal activity against Curvularia lunata. Liriodenine (5) displayed significant antifungal activity against Fusarium proliferatum and Fusarium oxysporum f. sp. vasinfectum, which is obviously better than positive control nystatin, suggesting that it had great potential to be developed into an effective and eco-friendly fungicide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aporfinas / Annonaceae Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aporfinas / Annonaceae Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos