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Patterns of regional cerebral hypoperfusion in early Parkinson's disease: Clinical implications.
Chung, Seok Jong; Kim, Su Hong; Park, Chan Wook; Lee, Hye Sun; Yun, Mijin; Kim, Yun Joong; Sohn, Young H; Jeong, Yong; Lee, Phil Hyu.
Afiliación
  • Chung SJ; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea; YONSEI BEYOND LAB, Yongin, South Korea.
  • Kim SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; KAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; Department of Radiology, Yeungnam University College
  • Park CW; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea.
  • Lee HS; Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.
  • Yun M; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim YJ; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea; YONSEI BEYOND LAB, Yongin, South Korea.
  • Sohn YH; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
  • Jeong Y; KAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; Department of Radiology, Yeungnam University College of Medicine, Daegu, South Korea; Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technolog
  • Lee PH; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: phlee@yuhs.ac.
Parkinsonism Relat Disord ; 121: 106024, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38377658
ABSTRACT

INTRODUCTION:

This study aimed to investigate whether regional cerebral perfusion patterns on early-phase 18F-FP-CIT PET scans, which is typically coupled to cerebral metabolism, predict the long-term prognosis of Parkinson's disease (PD).

METHODS:

We enrolled 397 drug-naïve patients with early-stage PD who underwent dual-phase 18F-FP-CIT PET scans. After quantifying the early-phase 18F-FP-CIT PET images, cluster analysis was performed to delineate the PD subtypes according to the patterns of regional cerebral perfusion. We compared the risk of developing levodopa-induced dyskinesia (LID), wearing-off, freezing of gait (FOG), and dementia between the PD subtypes.

RESULTS:

Cluster analysis classified patients into three subtypes cluster 1 (relatively preserved cortical uptake; n = 175), cluster 2 (decreased uptake in the frontal, parietal, and temporal regions; n = 151), and cluster 3 (decreased uptake in more extensive regions, additionally involving the lateral occipital regions; n = 71). Cluster 1 was characterized by a younger age-of-onset, less severe motor deficits, less severely decreased 18F-FP-CIT binding in the caudate, and better cognitive performance. Cluster 3 was characterized by an older age-of-onset, more severe motor deficits, and poorer cognitive performance. Cluster 2 was intermediate between clusters 1 and 3. Cox regression analyses demonstrated that clusters 2 and 3 had a higher risk for dementia conversion than cluster 1, whereas the risk for developing LID, wearing-off, and FOG did not differ among the clusters.

CONCLUSION:

The patterns of regional cerebral perfusion can provide information on long-term prognosis with regards to cognitive, but not motor aspects of patients with early-stage PD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Demencia Límite: Humans Idioma: En Revista: Parkinsonism Relat Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Demencia Límite: Humans Idioma: En Revista: Parkinsonism Relat Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido