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Evidence of altered salivary cytokine concentrations in Rett syndrome and associations with clinical severity.
Byiers, Breanne J; Merbler, Alyssa M; Barney, Chantel C; Frenn, Kristin A; Panoskaltsis-Mortari, Angela; Ehrhardt, Michael J; Feyma, Timothy J; Beisang, Arthur A; Symons, Frank.
Afiliación
  • Byiers BJ; Department of Educational Psychology, 56 E River Rd, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Merbler AM; Department of Educational Psychology, 56 E River Rd, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Barney CC; Gillette Children's Specialty Healthcare, 200 University Ave E, St. Paul, Minnesota, 55101, USA.
  • Frenn KA; Gillette Children's Specialty Healthcare, 200 University Ave E, St. Paul, Minnesota, 55101, USA.
  • Panoskaltsis-Mortari A; Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, 2450 Riverside Ave, University of Minnesota, Minneapolis, MN, 55454, USA.
  • Ehrhardt MJ; Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, 2450 Riverside Ave, University of Minnesota, Minneapolis, MN, 55454, USA.
  • Feyma TJ; Gillette Children's Specialty Healthcare, 200 University Ave E, St. Paul, Minnesota, 55101, USA.
  • Beisang AA; Gillette Children's Specialty Healthcare, 200 University Ave E, St. Paul, Minnesota, 55101, USA.
  • Symons F; Department of Educational Psychology, 56 E River Rd, University of Minnesota, Minneapolis, MN, 55455, USA.
Brain Behav Immun Health ; 1: 100008, 2020 Jan.
Article en En | MEDLINE | ID: mdl-38377412
ABSTRACT

Background:

Immune dysregulation may play a role in the development of Rett syndrome (RTT), a neurodevelopmental disorder caused by mutations of the MECP2 gene. Abnormal cytokine concentrations have been documented in the serum of individuals with RTT. Measurement of salivary cytokines has been investigated as a potential alternative approach to measurement in blood and serum, but it is unclear whether salivary cytokine concentrations can provide valid information about systemic immune function in neurodevelopmental disorders. The goal of this study was to evaluate the potential validity of salivary cytokines as biomarkers of immune dysregulation in RTT.

Methods:

Saliva samples from 16 individuals with RTT (all female; age range 2-40 years) and 16 healthy control females (age range 2-40 years) were analyzed for concentrations of 12 cytokines. Between-group differences in concentrations, and correlations with clinical severity in the RTT group were evaluated.

Results:

Concentrations of several salivary cytokines (IL-1ß, IL-6, IL-8, IL-10, GM-CSF, TNF-α, and VEGF) were increased in RTT compared to controls. The same cytokines showed significant positive correlations with clinical severity scores. There were no differences in concentrations of IL-2, IL-4, IL-5, IL-12p70, and IFN-γ.

Conclusion:

The results suggest that salivary cytokines may be a possible indicator of immune dysregulation in RTT. Future research should investigate whether these results can be applied to other neurodevelopmental disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Behav Immun Health Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Behav Immun Health Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos