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Elevated CD4+ T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19.
Zhang, Jie; Chang, Chun; Liang, Zhaoyuan; Hu, Tingting; Yin, Zhongnan; Liang, Ying; Zhang, Ting; Ding, Yanling; Li, Xianlong; Gai, Xiaoyan; Yang, Xiaoxue; Li, Xin; Dong, Xixuan; Ren, Jiaqi; Rao, Yafei; Wang, Jun; Yang, Jianling; Xue, Lixiang; Sun, Yongchang.
Afiliación
  • Zhang J; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Chang C; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Liang Z; Biobank, Peking University Third Hospital, Beijing, China.
  • Hu T; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Yin Z; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Liang Y; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Zhang T; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Ding Y; Biobank, Peking University Third Hospital, Beijing, China.
  • Li X; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Gai X; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Yang X; Biobank, Peking University Third Hospital, Beijing, China.
  • Li X; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Dong X; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Ren J; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Rao Y; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Wang J; Biobank, Peking University Third Hospital, Beijing, China.
  • Yang J; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Xue L; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
  • Sun Y; Biobank, Peking University Third Hospital, Beijing, China.
Aging Dis ; 2024 Feb 17.
Article en En | MEDLINE | ID: mdl-38377029
ABSTRACT
Aging is a critical risk factor for unfavorable clinical outcomes among COVID-19 patients and may impact vaccine efficacy. However, whether the senescence of T cells is associated with severe COVID-19 outcome in elderly individuals is unclear. Using flow cytometry, we analyzed the frequency of senescent T cells (Tsens) in peripheral blood from 100 hospitalized elderly COVID-19 patients and compared differences between those with mild/moderate and severe/critical illness. We also assessed correlations between the percentage of Tsens and the quantity and quality of spike-specific antibodies by ELISA, neutralizing antibody test kit, and ELISPOT assay respectively, the cytokine production profile of COVID-19 reactive T cells, and plasma soluble factors by cytometric bead array (CBA). Our study found a significantly elevated level of CD4+ Tsens in patients with severe/critical disease compared to those with mild/moderate illness. Patients with a higher level of CD4+ Tsens (>19.78%) showed a decreased survival rate compared to those with a lower level (≤19.78%). This is more pronounced among patients with breakthrough infections. The percentage of CD4+ Tsens was negatively correlated with spike-specific antibody titers, neutralization ability, and COVID-19 reactive IL-2+CD4+ T cells. In addition, spike-specific antibody levels were positively correlated with IL-2 producing T cells and plasma IL-2 amount. Mechanistically, with defective CD40L, T cells from patients with CD4+ Tsens >19.78% were unable to support B cell proliferation and differentiation. Our data demonstrate that the percentage of CD4+ Tsens in peripheral blood may serve as a reliable biomarker for the prognosis of severe COVID-19 patients, especially in breakthrough infections. Therefore, restoring the immune response of CD4+ Tsens may be key to preventing severe illness and improving vaccine efficacy in older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos