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Cardiac DTI using short-axis PROPELLER: A feasibility study.
Sadighi, Mehdi; Kara, Danielle; Mai, Dingheng; Nguyen, Khoi; Chen, Shi; Kwon, Deborah; Nguyen, Christopher.
Afiliación
  • Sadighi M; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Kara D; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Mai D; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Nguyen K; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio, USA.
  • Chen S; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Kwon D; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Nguyen C; Cardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Magn Reson Med ; 91(6): 2546-2558, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38376096
ABSTRACT

PURPOSE:

We aimed to develop a free-breathing (FB) cardiac DTI (cDTI) method based on short-axis PROPELLER (SAP) and M2 motion compensated spin-echo EPI (SAP-M2-EPI) to mitigate geometric distortion and eliminate aliasing in acquired diffusion-weighted (DW) images, particularly in patients with a higher body mass index (BMI). THEORY AND

METHODS:

The study involved 10 healthy volunteers whose BMI values fell into specific categories BMI <25 (4 volunteers), 25< BMI <28 (5 volunteers), and BMI >30 (1 volunteer). We compared DTI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and helix angle transmurality (HAT), between SAP-M2-EPI and M2-ssEPI. To evaluate the performance of SAP-M2-EPI in reducing geometric distortions in the left ventricle (LV) compared to CINE and M2-ssEPI, we utilized the DICE similarity coefficient (DSC) and assessed misregistration area.

RESULTS:

In all volunteers, SAP-M2-EPI yielded high-quality LV DWIs without aliasing, demonstrating significantly reduced geometric distortion (with an average DSC of 0.92 and average misregistration area of 90 mm2) and diminished signal loss due to bulk motion when compared to M2-ssEPI. DTI parameter maps exhibited consistent patterns across slices without motion related artifacts.

CONCLUSION:

SAP-M2-EPI facilitates free-breathing cDTI of the entire LV, effectively eliminating aliasing and minimizing geometric distortion compared to M2-ssEPI. Furthermore, it preserves accurate quantification of myocardial microstructure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión por Resonancia Magnética / Imagen de Difusión Tensora Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión por Resonancia Magnética / Imagen de Difusión Tensora Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos