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Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd(II) complexes.
Mansour, Ahmed M; Khaled, Rabaa M; Radacki, Krzysztof; Abo-Zeid, Mona A M; Shehab, Ola R; Mostafa, Gamal A E; Ali, Essam A; Abo-Elfadl, Mahmoud T.
Afiliación
  • Mansour AM; Department of Chemistry, United Arab Emirates University, Al-Ain, United Arab Emirates. Mansour_am@uaeu.ac.ae.
  • Khaled RM; Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
  • Radacki K; Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.
  • Abo-Zeid MAM; Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt.
  • Shehab OR; Genetics and Cytology Department, Genetic Engineering and Biotechnology Research Institute, National Research Centre, Giza, Egypt.
  • Mostafa GAE; Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
  • Ali EA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Abo-Elfadl MT; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Dalton Trans ; 53(11): 5073-5083, 2024 Mar 12.
Article en En | MEDLINE | ID: mdl-38375910
ABSTRACT
A series of Pd(II) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde-N4-phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes. Various auxiliary ligands were substituted in order to investigate the impact of the character of the ligand on the cytotoxicity of this class of Pd(II) complexes. The iodo complex was the most cytotoxic compound towards the Caco-2 cell line in this study. The improved apoptosis and necrosis cell modes were in accordance with the fragmentation results of DNA, which revealed increased fragmentation terminals, especially in isothiocyanate and tetrazole-thiolato complexes. After 24 hours, at half the IC50 of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiosemicarbazonas / Complejos de Coordinación / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Dalton Trans Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiosemicarbazonas / Complejos de Coordinación / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Dalton Trans Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos Pais de publicación: Reino Unido