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Investigation of the pathogenesis of ADAR1 gene in dyschromatosis symmetrica hereditaria.
Zhang, Jia; Jiang, Chengyi; Wang, Zhen; Fang, Biqing; He, Jin; Li, Ming.
Afiliación
  • Zhang J; Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Jiang C; Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Wang Z; Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Fang B; Department of Dermatology, QuanZhou Women's and Children's Hospital, Quanzhou, China.
  • He J; Department of Pediatric Orthopaedics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Li M; Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Exp Dermatol ; 33(2): e15031, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38375898
ABSTRACT
The pathogenesis of dyschromatosis symmetrica hereditaria (DSH) has not been well defined. In this study, we sought to investigate the influence of the ADAR1 gene on DSH both in vitro and in vivo. Morpholino knockdown of adar1 in zebrafish produced phenotypes characterized by polarity changes, and abnormal migration and distribution of melanocytes. Differential expression of C-KIT and distinct patterns of apoptosis between hyperpigmented and hypopigmented areas in DSH patient were detected by means of immunohistochemical methods and TUNEL assays, respectively. This study revealed that adar1 knockdown in a zebrafish model resulted in abnormal migration and changes in the cell polarity of melanocytes, and provided novel insight into the mechanism of DSH pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Pigmentación / Pez Cebra / Adenosina Desaminasa / Proteínas de Unión al ARN Límite: Animals / Humans Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Dinamarca
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Pigmentación / Pez Cebra / Adenosina Desaminasa / Proteínas de Unión al ARN Límite: Animals / Humans Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Dinamarca