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In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing.
Li, Molin; Shi, Lin; Chen, Xianghui; Yi, Dan; Ding, Yufei; Chen, Jian; Xing, Guanghui; Chen, Siming; Wang, Li; Zhang, Yongyi; Zhu, Yaqiong; Wang, Yuexiang.
Afiliación
  • Li M; Medical School of Chinese PLA, Beijing, China.
  • Shi L; Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Chen X; State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
  • Yi D; Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Ding Y; Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Chen J; Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Xing G; Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Chen S; Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Wang L; School of Medicine, Nankai University, Tianjin, China.
  • Zhang Y; Department of Ultrasound, the Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Zhu Y; Department of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Wang Y; Medical School of Chinese PLA, Beijing, China.
Commun Biol ; 7(1): 205, 2024 Feb 20.
Article en En | MEDLINE | ID: mdl-38374439
ABSTRACT
Although platelet-rich plasma-derived exosomes (PRP-Exos) hold significant repair potential, their efficacy in treating rotator cuff tear (RCT) remains unknown. In light of the potential for clinical translation of fibrin gel and PRP-Exos, we evaluated their combined impact on RCT healing and explored suitable gel implantation techniques. In vitro experiments demonstrated that PRP-Exos effectively enhanced key phenotypes changes in tendon stem/progenitor cells. Multi-modality imaging, including conventional ultrasound, shear wave elastography ultrasound, and micro-computed tomography, and histopathological assessments were performed to collectively evaluate the regenerative effects on RCT. The regenerated tendons exhibited a well-ordered structure, while bone and cartilage regeneration were significantly improved. PRP-Exos participated in the healing process of RCT. In-situ gelation of fibrin gel-encapsulated PRP-Exos at the bone-tendon interface during surgery proved to be a feasible gel implantation method that benefits the healing outcome. Comprehensive multi-modality postoperative evaluations were necessary, providing a reliable foundation for post-injury repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma Rico en Plaquetas / Exosomas / Lesiones del Manguito de los Rotadores Límite: Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma Rico en Plaquetas / Exosomas / Lesiones del Manguito de los Rotadores Límite: Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido