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Consumption of Apigenin Prevents Radiation-induced Gut Dysbiosis in Male C57BL/6J Mice Exposed to Silicon Ions.
Rithidech, Kanokporn Noy; Peanlikhit, Tanat; Honikel, Louise; Li, Jinyu; Liu, Jingxuan; Karakach, Tobias; Zimmerman, Thomas; Welsh, James.
Afiliación
  • Rithidech KN; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Peanlikhit T; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Honikel L; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Li J; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Liu J; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Karakach T; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada B3H 4R2.
  • Zimmerman T; Pathology Department, Stony Brook University, Stony Brook, New York 11794-8691.
  • Welsh J; Division of Laboratory Animal Resources, Stony Brook University, Stony Brook, New York 11794-8611.
Radiat Res ; 201(4): 317-329, 2024 04 01.
Article en En | MEDLINE | ID: mdl-38373016
ABSTRACT
The search for medical treatments to prevent radiation-induced damage to gastrointestinal tissue is crucial as such injuries can be fatal. This study aimed to investigate the effects of apigenin (AP) on the gut microbiome of irradiated mice, as it is a promising radiation countermeasure. Male C57BL/6J mice were divided into four groups, with six mice in each group. Two groups were given food with apigenin (20 mg/kg body weight or AP 20) before and after exposure to 0 or 50 cGy of silicon (28Si) ions, while another two groups of mice received regular diet without apigenin (0 mg/kg body weight or AP 0) before and after irradiation. The duodenum, the primary site for oral AP absorption, was collected from each mouse seven days after radiation exposure. Using 16S rRNA amplicon sequencing, we found significant differences in microbial diversity among groups. Firmicutes and Bacteroidetes were the major phyla for all groups, while actinobacterial and proteobacterial sequences represented only a small percentage. Mice not given dietary apigenin had a higher Firmicutes and Bacteroidetes (F/B) ratio and an imbalanced duodenal microbiota after exposure to radiation, while irradiated mice given apigenin had maintained homeostasis of the microbiota. Additionally, irradiated mice not given apigenin had decreased probiotic bacteria abundance and increased inflammation, while apigenin-supplemented mice had reduced inflammation and restored normal histological structure. In conclusion, our results demonstrate the potential of dietary apigenin as a countermeasure against radiation-induced gut injuries due to its anti-inflammatory activity, reduction of gut microbiota dysbiosis, and increase in probiotic bacteria (e.g., Lachnospiraceae, Muribaculaceae and Bifidobacteriaceae).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Apigenina Límite: Animals Idioma: En Revista: Radiat Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Apigenina Límite: Animals Idioma: En Revista: Radiat Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos