What Single Cell RNA Sequencing Has Taught Us about Chronic Obstructive Pulmonary Disease.
Tuberc Respir Dis (Seoul)
; 87(3): 252-260, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38369875
ABSTRACT
Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endophenotypes, each driven by specific molecular networks and processes. Therapeutic discovery in COPD has lagged behind other disease areas owing to a lack of understanding of its pathobiology and scarcity of biomarkers to guide therapies. Single cell RNA sequencing (scRNA-seq) is a powerful new tool to identify important cellular and molecular networks that play a crucial role in disease pathogenesis. This paper provides an overview of the scRNA-seq technology and its application in COPD and the lessons learned to date from scRNA-seq experiments in COPD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Tuberc Respir Dis (Seoul)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación: