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Comparison In Vitro Fertilization Outcomes between DouStim and Minimal Stimulation Protocols in Poor Ovarian Responders: A Randomized Clinical Trial.
Saharkhiz, Nasrin; Salehpoor, Saghar; Hosseini, Sedigheh; Nazari, Leila; Sheibani, Samaneh; Doohandeh, Tahereh.
Afiliación
  • Saharkhiz N; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Salehpoor S; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hosseini S; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nazari L; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sheibani S; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Doohandeh T; Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: taherehdoohandeh@sbmu.ac.ir.
Int J Fertil Steril ; 18(2): 135-139, 2024 Feb 02.
Article en En | MEDLINE | ID: mdl-38368516
ABSTRACT

BACKGROUND:

Various protocols have been approved to improve the response rate leading to successful fertilization in poor ovarian responders (PORs). The application of double ovarian stimulation (DuoStim) in the follicular and luteal phases of the same ovarian cycle has been shown as an intriguing option to achieve more oocyte retrievals in the shortest time. The aim of the current study is to compare the outcomes of different protocols, minimal stimulation (MS) and Duostim. MATERIALS AND

METHODS:

This randomized clinical trial was performed on 42 in vitro fertilization (IVF) candidates with POR diagnosis. Patients were classified into two equal groups and treated with the DuoStim protocol and MS protocol. The IVF outcomes, including retrieved follicles, oocytes, metaphase II (MII) oocytes and embryos, were compared between these groups.

RESULTS:

The patients' characteristics including age, anti-mullerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and antral follicle count (AFC) were collected and compared. It showed there was no significant difference between the two groups baseline characteristics (P>0.05). We observed that the DuoStim protocol resulted in a significantly higher score in comparison with the MS protocols , including the number of follicles (6.23 ± 2.93 vs. 1.77 ± 1.66, P<0.001), retrieved oocytes (3.86 ± 2.57 vs. 1.68 ± 1.58, P=0.002), MII oocytes (3.36 ± 2.42 vs. 1.27 ± 1.27, P=0.001) and obtained embryos (2.04 ± 1.64 vs. 0.77 ± 0.86, P=0.003).

CONCLUSION:

The DuoStim protocol is a favourable and time saving plan that is associated with more oocytes in a single stimulation cycle. The DuoStim protocol significantly can result in more frequent MII oocytes and embryos. We figured that the higher number of oocytes and embryos might have led to a higher rate of pregnancy (registration number IRCT20200804048303N1).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Fertil Steril Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Fertil Steril Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán