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Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.
Rotterman, Travis M; Haley-Johnson, Zoë; Pottorf, Tana S; Chopra, Tavishi; Chang, Ethan; Zhang, Shannon; McCallum, William M; Fisher, Sarah; Franklin, Haley; Alvarez, Myriam; Cope, Timothy C; Alvarez, Francisco J.
Afiliación
  • Rotterman TM; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30318, USA.
  • Haley-Johnson Z; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Pottorf TS; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Chopra T; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Chang E; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30318, USA.
  • Zhang S; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • McCallum WM; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Fisher S; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Franklin H; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA; The Alabama College of Osteopathic Medicine, Dothan, AL 36301, USA.
  • Alvarez M; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
  • Cope TC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30318, USA; W.H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30332, USA.
  • Alvarez FJ; Department of Cell Biology, Emory University, Atlanta, GA 30322, USA. Electronic address: francisco.j.alvarez@emory.edu.
Cell Rep ; 43(2): 113776, 2024 Feb 27.
Article en En | MEDLINE | ID: mdl-38367237
ABSTRACT
Microglia-mediated synaptic plasticity after CNS injury varies depending on injury severity, but the mechanisms that adjust synaptic plasticity according to injury differences are largely unknown. This study investigates differential actions of microglia on essential spinal motor synaptic circuits following different kinds of nerve injuries. Following nerve transection, microglia and C-C chemokine receptor type 2 signaling permanently remove Ia axons and synapses from the ventral horn, degrading proprioceptive feedback during motor actions and abolishing stretch reflexes. However, Ia synapses and reflexes recover after milder injuries (nerve crush). These different outcomes are related to the length of microglia activation, being longer after nerve cuts, with slower motor-axon regeneration and extended expression of colony-stimulating factor type 1 in injured motoneurons. Prolonged microglia activation induces CCL2 expression, and Ia synapses recover after ccl2 is deleted from microglia. Thus, microglia Ia synapse removal requires the induction of specific microglia phenotypes modulated by nerve regeneration efficiencies. However, synapse preservation was not sufficient to restore the stretch-reflex function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Microglía Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Microglía Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos