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The relationship between advanced liver fibrosis and osteoporosis in type 2 diabetes patients with MAFLD.
Pan, Binjing; Zhao, Yangting; Chen, Chongyang; Cai, Jing; Li, Kai; Wang, Yawen; Liu, Jingfang.
Afiliación
  • Pan B; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Zhao Y; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Chen C; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Cai J; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Li K; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Wang Y; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
  • Liu J; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China. ljf824168@126.com.
Endocrine ; 85(1): 206-221, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38367145
ABSTRACT

PURPOSE:

To investigate the relationship between advanced liver fibrosis and osteoporosis in metabolic-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM).

METHODS:

A total of 1144 T2DM patients were divided into the MAFLD and non-MAFLD groups, 460 T2DM patients with MAFLD (277 males aged ≥50 years and 183 postmenopausal females) were divided into N1 (advanced liver fibrosis excluded), N2 (indeterminate advanced liver fibrosis), and N3 (advanced liver fibrosis) groups according to the non-alcoholic fatty liver fibrosis score (NFS), the differences in bone mineral density (BMD) levels and prevalence of osteoporosis were compared. Based on the tertile levels of BMD of the lumbar spine (L), T2DM patients were divided into three groups (T1, T2, and T3), and the differences in the prevalence of advanced liver fibrosis were compared.

RESULTS:

The BMD levels of the L4, and L1-4 in the MAFLD group were lower than those of the non-MAFLD groups in male and female T2DM patients .The BMD levels of the total hip, L4, and L1-4 in the N3 group were lower than those of the N2 and N1 groups in male and female T2DM patients with MAFLD, and the prevalence of osteoporosis in the N3 group of males was higher than that in the N1 group. The BMD levels of the total hip, L4, and L1-4 were negatively correlated with NFS in both males and females. The BMD levels of the total hip and L4 in males, and the BMD level of L4 in females were negatively associated with NFS. The prevalence of advanced liver fibrosis was higher in the T1 group than in the T2 and T3 groups in T2DM patients with MAFLD.

CONCLUSION:

The BMD levels in male aged ≥50 years or postmenopausal female diabetic patients with MAFLD were negatively correlated with the degree of advanced liver fibrosis, which means an increased risk of liver fibrosis with decreasing BMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Densidad Ósea / Diabetes Mellitus Tipo 2 / Enfermedad del Hígado Graso no Alcohólico / Cirrosis Hepática Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Densidad Ósea / Diabetes Mellitus Tipo 2 / Enfermedad del Hígado Graso no Alcohólico / Cirrosis Hepática Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos