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Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway.
Liang, Jie; Chen, Ting; Xu, Honglei; Wang, Tingfang; Gong, Qi; Li, Tingting; Liu, Xiaoyan; Wang, Jing; Wang, Yun; Xiong, Liyan.
Afiliación
  • Liang J; Department of Medicine, Linfen Vocational and Technical College, Linfen, Shanxi, 041000, China.
  • Chen T; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Xu H; Medical Security Center, The No. 983th Hospital of Joint Logistics Support Forces of Chinese PLA, Tianjin, 300142, China.
  • Wang T; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Gong Q; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Li T; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Liu X; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Wang J; Department of Pharmacy, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700, China.
  • Wang Y; School of Medicine, Shanghai University, Shanghai, 200444, China.
  • Xiong L; School of Medicine, Shanghai University, Shanghai, 200444, China.
Mol Nutr Food Res ; 68(6): e2300553, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38366962
ABSTRACT
SCOPE Nonalcoholic steatohepatitis (NASH) is an increasingly common chronic liver disease in which hepatic fibrosis is the major pathological change. The transforming growth factor ß (TGF-ß)/mall mothers against decapentaplegic (Smad) signaling is the main effector of fibrosis. Although the antifibrotic effect of echinacoside (Ech) on the liver has been indicated previously, the cellular and molecular mechanisms remain unclear. This study aims to investigate both in vivo and in vitro antifibrotic properties of Ech. METHODS AND

RESULTS:

Cell viability and scratch/wound assays show that Ech significantly inhibits the proliferation, migration, and activation of human hepatic stellate LX-2 cells. In mice with high-fat diet-induced hepatic fibrosis, Ech treatment attenuates the progression of liver injury, inflammation, and fibrosis. Furthermore, transcriptome analysis and subsequent functional validation demonstrate that Ech achieves antifibrotic effects by the activin receptor type-2A (ACVR2A)-mediated TGF-ß1/Smad signaling pathway; ultimately, ACVR2A is demonstrated to be an important target for hepatic fibrosis by inhibiting and inducing the expression of ACVR2A in LX-2 cells.

CONCLUSION:

Ech exerts potent antifibrotic effects by inhibiting the ACVR2A-mediated TGF-ß1/Smad signaling axis and may serve as an alternative treatment for hepatic fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Smad / Factor de Crecimiento Transformador beta1 / Glicósidos Límite: Animals / Humans Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Smad / Factor de Crecimiento Transformador beta1 / Glicósidos Límite: Animals / Humans Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania