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The association between KRAS and histopathological growth patterns and the impact on resection margins around vasculature and bile ducts in colorectal liver metastases.
Wong, Pearl; Wong, Geoffrey Yuet Mun; Toon, Christopher W; Chapuis, Pierre; Hugh, Thomas J.
Afiliación
  • Wong P; Upper Gastrointestinal Surgery Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Wong GYM; Upper Gastrointestinal Surgery Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Toon CW; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  • Chapuis P; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  • Hugh TJ; Anatomical Pathology Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
ANZ J Surg ; 94(4): 560-565, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38366706
ABSTRACT
The liver is the most frequent and often the only site of distant disease in colorectal cancer and, of all treatment protocols currently in use, resection is the most likely to result in long-term cure. Within the liver, tumour proximity to major vasculature and biliary structures poses a resection challenge, requiring a balance of achieving negative margins while preserving adequate vascular circulation and biliary drainage. The focus on parenchymal sparing resections are important but just as important may be the 'biological' behaviour of the tumour. In colorectal liver metastases (CRLM), biomarkers such as the Kirsten rat sarcoma oncogene homologue (KRAS) gene and histological growth patterns (HGPs) further improve the prognostication after resection. However, to date, the association between the KRAS status and HGPs in CRLM and their impact on resection margins around major vasculature or biliary structures in terms of overall survival and recurrence rates are unclear. The aim of this review was to explore the available evidence for the association between KRAS and HGPs in CRLM and attempt to define their impact on resection margins near major structures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: ANZ J Surg Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: ANZ J Surg Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia