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Skin lightening properties of zerumbone cream: A placebo-controlled study.
Kuek, Wee Nie; Tiang, Yi Ru; Yow, Hui Yin; Tan, Li Kar Stella; How, Chee Wun; Looi, Qi Hao Daniel; Foo, Jhi Biau.
Afiliación
  • Kuek WN; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
  • Tiang YR; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
  • Yow HY; Department of Pharmaceutical Life Sciences, Faculty of Health and Medical Sciences, University Malaya, Kuala Lumpur, Malaysia.
  • Tan LKS; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
  • How CW; Digital Health and Medical Advancements Impact Lab, Taylor's University, Subang Jaya, Malaysia.
  • Looi QHD; School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
  • Foo JB; CytoHealth Centre of Research Sdn. Bhd., Lab 6, DMC Level 2, Taman Teknologi MRANTI, Kuala Lumpur, Malaysia.
J Cosmet Dermatol ; 23(6): 2117-2124, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38366687
ABSTRACT

OBJECTIVE:

Despite the demonstrated anti-melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single-blind approach.

METHODS:

Twenty-six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18.

RESULTS:

Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well-received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p < 0.05) after 1 week compared to the initial baseline. Furthermore, after 2 weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (p < 0.05). No adverse effects were observed in the group using ZER cream.

CONCLUSION:

ZER demonstrated significant potential as a skin-lightening agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Pigmentación de la Piel / Preparaciones para Aclaramiento de la Piel / Crema para la Piel Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Pigmentación de la Piel / Preparaciones para Aclaramiento de la Piel / Crema para la Piel Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido