Your browser doesn't support javascript.
loading
The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.
Cabrera-Mendoza, Brenda; Wendt, Frank R; Pathak, Gita A; Yengo, Loic; Polimanti, Renato.
Afiliación
  • Cabrera-Mendoza B; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Wendt FR; VA CT Healthcare System, West Haven, CT, USA.
  • Pathak GA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Yengo L; VA CT Healthcare System, West Haven, CT, USA.
  • Polimanti R; Department of Anthropology, University of Toronto, Toronto, Ontario, Canada.
Nat Hum Behav ; 8(5): 976-987, 2024 May.
Article en En | MEDLINE | ID: mdl-38366106
ABSTRACT
To investigate assortative mating (AM), participation bias and socioeconomic status (SES) with respect to the genetics of behavioural and psychiatric traits, we estimated AM signatures using gametic phase disequilibrium and within-spouses and within-siblings polygenic risk score correlation analyses, also performing a SES conditional analysis. The cross-method meta-analysis identified AM genetic signatures for multiple alcohol-related phenotypes, bipolar disorder, major depressive disorder, schizophrenia and Tourette syndrome. Here, after SES conditioning, we observed changes in the AM genetic signatures for maximum habitual alcohol intake, frequency of drinking alcohol and Tourette syndrome. We also observed significant gametic phase disequilibrium differences between UK Biobank mental health questionnaire responders versus non-responders for major depressive disorder and alcohol use disorder. These results highlight the impact of AM, participation bias and SES on the polygenic risk of behavioural and psychiatric traits, particularly in alcohol-related traits.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clase Social / Herencia Multifactorial Límite: Female / Humans / Male Idioma: En Revista: Nat Hum Behav Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clase Social / Herencia Multifactorial Límite: Female / Humans / Male Idioma: En Revista: Nat Hum Behav Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido