Your browser doesn't support javascript.
loading
The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT).
Bianchi, Alessia; Matranga, Domenica; Patti, Francesco; Maniscalco, Laura; Pilotto, Silvy; Di Filippo, Massimiliano; Zaffaroni, Mauro; Annovazzi, Pietro; Bertolotto, Antonio; Gasperini, Claudio; Quartuccio, Esmeralda; Centonze, Diego; Fantozzi, Roberta; Gajofatto, Alberto; Gobbin, Francesca; Landi, Doriana; Granella, Franco; Buccafusca, Maria; Marfia, Girolama Alessandra; Chisari, Clara; Naldi, Paola; Bergamaschi, Roberto; Greco, Giacomo; Zarbo, Ignazio Roberto; Rizzo, Vincenzo; Ulivelli, Monica; Bezzini, Daiana; Florio, Lucia; Turazzini, Michelangelo; Di Gregorio, Maria; Pugliatti, Maura; Salemi, Giuseppe; Ragonese, Paolo.
Afiliación
  • Bianchi A; Department of Biomedicine, Neurosciences and Advanced Diagnostic, University of Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy.
  • Matranga D; Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, University College London, London, UK.
  • Patti F; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
  • Maniscalco L; Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy.
  • Pilotto S; Department of Biomedicine, Neurosciences and Advanced Diagnostic, University of Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy.
  • Di Filippo M; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
  • Zaffaroni M; Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy.
  • Annovazzi P; Multiple Sclerosis Centre, Hospital of Gallarate, ASST Della Valle Olona, Gallarate, Italy.
  • Bertolotto A; Multiple Sclerosis Centre, Hospital of Gallarate, ASST Della Valle Olona, Gallarate, Italy.
  • Gasperini C; Ospedale Koelliker, Turin and Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy.
  • Quartuccio E; Department of Neurology, San Camillo-Forlanini Hospital, Rome, Italy.
  • Centonze D; Department of Neurology, San Camillo-Forlanini Hospital, Rome, Italy.
  • Fantozzi R; Unit of Neurology, Department of Neurorehabilitation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, Pozzilli, Italy.
  • Gajofatto A; Department of Systems Medicine, Tor Vergata University, Rome, Italy.
  • Gobbin F; Unit of Neurology, Department of Neurorehabilitation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, Pozzilli, Italy.
  • Landi D; Department of Systems Medicine, Tor Vergata University, Rome, Italy.
  • Granella F; Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Buccafusca M; Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Marfia GA; Department of Systems Medicine, Tor Vergata University, Rome, Italy.
  • Chisari C; Multiple Sclerosis Clinical and Research Unit, Tor Vergata University Hospital, Rome, Italy.
  • Naldi P; Department of Medicine and Surgery, University of Parma, Parma, Italy.
  • Bergamaschi R; Department of Clinical and Experimental Medicine, Unit of Neurology and Neuromuscular Diseases, University of Messina, Messina, Italy.
  • Greco G; Department of Systems Medicine, Tor Vergata University, Rome, Italy.
  • Zarbo IR; Multiple Sclerosis Clinical and Research Unit, Tor Vergata University Hospital, Rome, Italy.
  • Rizzo V; Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy.
  • Ulivelli M; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
  • Bezzini D; IRCCS Mondino Foundation, Pavia, Italy.
  • Florio L; IRCCS Mondino Foundation, Pavia, Italy.
  • Turazzini M; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
  • Di Gregorio M; Department of Clinical and Experimental Medicine, Unit of Neurology and Neuromuscular Diseases, University of Messina, Messina, Italy.
  • Pugliatti M; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
  • Salemi G; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
  • Ragonese P; IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
J Neurol ; 271(5): 2182-2194, 2024 May.
Article en En | MEDLINE | ID: mdl-38366072
ABSTRACT

OBJECTIVE:

Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case-control study involving 18 Italian MS Centres investigated MS course by ethnicity and native-country economic status in foreign-born patients living in Italy.

METHODS:

We identified 457 MS patients who migrated to Italy and 893 age- and sex-matched native-born Italian patients. In our population, 1225 (93.2%) subjects were White Europeans and White Northern Americans (WENA) and 89 (6.8%) patients were from other ethnical groups (OEG); 1109 (82.1%) patients were born in a high-income (HI) Country and 241 (17.9%) in a low-middle-income (LMI) Country. Medical records and patients interviews were used to collect demographic and disease data.

RESULTS:

We included 1350 individuals (973 women and 377 men); mean (SD) age was 45.0 (11.7) years. At onset, 25.45% OEG patients vs 12.47% WENA (p = 0.039) had > 3 STIR spine lesions. At recruitment, the same group featured mean (SD) EDSS score of 2.85 (2.23) vs 2.64 (2.28) (p = 0.044) reached in 8.9 (9.0) vs 12.0 (9.0) years (p = 0.018) and underwent 1.10 (4.44) vs. 0.99 (0.40) annual MRI examinations (p = 0.035). At disease onset, patients from LMI countries had higher EDSS score than HI patients (2.40 (1.43) vs 1.99 (1.17); p = 0.032).

DISCUSSION:

Our results suggested that both ethnicity and socio-economic status of native country shape MS presentation and course and should be considered for an appropriate management of patients. To the best of our knowledge, this is the first study reporting on the impact of ethnicity in MS at an individual level and beyond an ecological population-perspective.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: J Neurol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: J Neurol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania