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Mosquito midgut stem cell cellular defense response limits Plasmodium parasite infection.
Barletta, Ana-Beatriz F; Smith, Jamie C; Burkart, Emily; Bondarenko, Simon; Sharakhov, Igor V; Criscione, Frank; O'Brochta, David; Barillas-Mury, Carolina.
Afiliación
  • Barletta AF; Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA. anabeatriz.barlettaferreira@nih.gov.
  • Smith JC; Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Burkart E; Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Bondarenko S; Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24060, USA.
  • Sharakhov IV; Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24060, USA.
  • Criscione F; Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • O'Brochta D; Institute for Bioscience and Biotechnology Research and Department of Entomology University of Maryland-College Park, Rockville, MD, 20850, USA.
  • Barillas-Mury C; Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA. cbarillas@niaid.nih.gov.
Nat Commun ; 15(1): 1422, 2024 Feb 16.
Article en En | MEDLINE | ID: mdl-38365823
ABSTRACT
A novel cellular response of midgut progenitors (stem cells and enteroblasts) to Plasmodium berghei infection was investigated in Anopheles stephensi. The presence of developing oocysts triggers proliferation of midgut progenitors that is modulated by the Jak/STAT pathway and is proportional to the number of oocysts on individual midguts. The percentage of parasites in direct contact with enteroblasts increases over time, as progenitors proliferate. Silencing components of key signaling pathways through RNA interference (RNAi) that enhance proliferation of progenitor cells significantly decreased oocyst numbers, while limiting proliferation of progenitors increased oocyst survival. Live imaging revealed that enteroblasts interact directly with oocysts and eliminate them. Midgut progenitors sense the presence of Plasmodium oocysts and mount a cellular defense response that involves extensive proliferation and tissue remodeling, followed by oocysts lysis and phagocytosis of parasite remnants by enteroblasts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parásitos / Plasmodium / Malaria / Anopheles Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parásitos / Plasmodium / Malaria / Anopheles Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido