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Major depressive disorder with hypersomnolence complaint: A comparison study with non-depressed individuals examining objective biomarkers.
Bazin, Balthazar; Frija-Masson, Justine; Benzaquen, Helene; Maruani, Julia; Micoulaud Franchi, Jean-Arthur; Lopez, Régis; Philip, Pierre; Bourgin, Patrice; Lejoyeux, Michel; d'Ortho, Marie-Pia; Geoffroy, Pierre A.
Afiliación
  • Bazin B; GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France. Electronic address: balthazar.bazin@ghu-paris.fr.
  • Frija-Masson J; Université Paris Cité, Inserm, NeuroDiderot, FHU I2-D2, F-75019 Paris, France; Service de Physiologie Explorations Fonctionnelles et Centre du Sommeil, Assistance Publique-Hôpitaux de Paris, Hopital Bichat - Claude Bernard, F-75018 Paris, France.
  • Benzaquen H; Service de Physiologie Explorations Fonctionnelles et Centre du Sommeil, Assistance Publique-Hôpitaux de Paris, Hopital Bichat - Claude Bernard, F-75018 Paris, France.
  • Maruani J; GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France; Université Paris Cité, Inserm, NeuroDiderot, FHU I2-D2, F-75019 Paris, France; Département de psychiatrie et d'addictologie, Assistance Publique-Hôpitaux de Paris, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Clau
  • Micoulaud Franchi JA; CNRS, SANPSY, UMR 6033, Bordeaux, France; CHU de Bordeaux, Centre Hypersomnies Rares, Bordeaux, France; INSERM CIC1401, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
  • Lopez R; Department of Neurology, Sleep Disorders Center, Gui-de-Chauliac Hospital, CHU Montpellier, F-34000 Montpellier, France; Inserm, U1061, Université Montpellier 1, F-34000 Montpellier, France.
  • Philip P; CNRS, SANPSY, UMR 6033, Bordeaux, France; CHU de Bordeaux, Centre Hypersomnies Rares, Bordeaux, France; INSERM CIC1401, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France; Sleep, Addiction and Neuropsychiatry, University of Bordeaux, Bordeaux, France.
  • Bourgin P; Sleep Disorders Center - CIRCSom (International Research Center for ChronoSomnology), University Hospital of Strasbourg 1, Strasbourg, France; CNRS UPR 3212 & Strasbourg University, Institute for Cellular and Integrative Neurosciences, Strasbourg, France.
  • Lejoyeux M; GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France; Université Paris Cité, Inserm, NeuroDiderot, FHU I2-D2, F-75019 Paris, France; Département de psychiatrie et d'addictologie, Assistance Publique-Hôpitaux de Paris, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Clau
  • d'Ortho MP; Université Paris Cité, Inserm, NeuroDiderot, FHU I2-D2, F-75019 Paris, France; Service de Physiologie Explorations Fonctionnelles et Centre du Sommeil, Assistance Publique-Hôpitaux de Paris, Hopital Bichat - Claude Bernard, F-75018 Paris, France.
  • Geoffroy PA; GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France; Université Paris Cité, Inserm, NeuroDiderot, FHU I2-D2, F-75019 Paris, France; Département de psychiatrie et d'addictologie, Assistance Publique-Hôpitaux de Paris, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Clau
J Affect Disord ; 352: 422-428, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38364977
ABSTRACT

BACKGROUND:

Hypersomnolence is common in major depressive disorder (MDD), associated with more severe episodes, suicide and antidepressant resistance. Nevertheless, few studies used polysomnography (PSG) and multiple sleep latency test (MSLT) to characterize these patients. In this context, we compared patients visiting a sleep center for hypersomnolence complaint with MDD (HSC/MDD+) and without MDD (HSC/MDD-).

METHODS:

HSC/MDD+ and HSC/MDD- groups were defined according to DSM-5 criteria and CES-D scale, and had a 30 h-PSG with ad libitum-sleep and PSG followed by MLST.

RESULTS:

HSC/MDD+ had an increased self-declared total sleep time (sTST) of about 10 h30 similar to HSC/MDD- (630.8 ± 17.3 min-vs-616.5 ± 18.1 min, respectively, p = 0.39). Nevertheless, their objective TST (oTST) on ad libitum PSG was significantly longer and about 10 h50 (648.6 ± 23.9 min-vs-587.4 ± 19.0 min, respectively, p = 0.038). HSC/MDD+ also significantly better estimated their sleep duration, with a lower difference between their sTST and oTST compared to HSC/MDD- (10.0 ± 1.7 %-vs-17.4 ± 2.1 %, respectively, p = 0.009) and confirmed significantly more frequently the hypersomnia diagnosis -i.e. oTST>10H- (82.6 ± 8.1 %-vs-54.6 ± 10.9 %, respectively, p = 0.046). Using the Kupfer index (KI), we confirmed a reduced REM sleep latency in patients MDD/HSC+ (15.2 ± 10.0 %-vs-2.3 ± 2.3 %, respectively, p = 0.039). Both groups had comparable increased diurnal sleepiness assessed with the Epworth scale (14.1 ± 1.1-vs-14.8 ± 1.1, respectively, p = 0.65). HSC/MDD+ had less MSLT sleep latency <8 min (9.1 ± 5.1 %-vs-27.3 ± 6.8 %, respectively, p = 0.048).

LIMITATIONS:

Retrospective cross-sectional study.

CONCLUSIONS:

HSC/MDD+ accurately estimated their sleep duration, objectively confirmed hypersomnia and may specifically had a decreased Kupfer index.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Trastornos de Somnolencia Excesiva Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Trastornos de Somnolencia Excesiva Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos