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Prognostic value and therapeutic potential of IAP family in head and neck squamous cell carcinoma.
Yu, Xiaoqian; Cao, Weiwei; Yang, Xuejie; Yu, Canping; Jiang, Wenying; Guo, Hongbin; He, Xiaoyun; Mei, Cheng; Ou, Chunlin.
Afiliación
  • Yu X; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • Cao W; Department of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha 410008, Hunan, China.
  • Yang X; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • Yu C; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • Jiang W; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • Guo H; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • He X; Departments of Ultrasound Imaging, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
  • Mei C; Department of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha 410008, Hunan, China.
  • Ou C; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Aging (Albany NY) ; 16(4): 3674-3693, 2024 02 15.
Article en En | MEDLINE | ID: mdl-38364254
ABSTRACT
Head and neck squamous cell carcinoma (HNSCC) ranks as the eighth most prevalent malignancy globally and has the eighth greatest fatality rate when compared to all other forms of cancer. The inhibitor of apoptosis protein (IAP) family comprises a collection of apoptosis-negative modulators characterized by at least one single baculovirus IAP repeat (BIR) domain in its N-terminal region. While the involvement of the IAP family is associated with the initiation and progression of numerous tumours, its specific role in HNSCC remains poorly understood. Thus, this study aimed to comprehensively examine changes in gene expression, immunomodulatory effects, prognosis, and functional enrichment of HNSCC utilising bioinformatics analysis. Elevated levels of distinct IAP family members were observed to varying degrees in HNSCC, with high BIRC2 expression indicating a worse prognosis. Additionally, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to probe the enrichment of gene expression and biological processes related to the IAP family in HNSCC. The infiltration levels of immune cells were shown to be strongly associated with the IAP gene expression, as determined by subsequent analysis. Hence, BIRC2 could be an effective immunotherapy target for HNSCC. Collectively, novel knowledge of the biological roles and prognostic implications of IAP family members in HNSCC is presented in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos