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Risk of Autoimmune Disease in Research-Identified Cases of Autism Spectrum Disorder: A Longitudinal, Population-Based Birth Cohort Study.
Villarreal, Veronica R; Katusic, Maja Z; Myers, Scott M; Weaver, Amy L; Nocton, James J; Voigt, Robert G.
Afiliación
  • Villarreal VR; Division of Pediatric Neurology/Neurodevelopment, Department of Pediatrics, Baylor College of Medicine, San Antonio, TX.
  • Katusic MZ; Department of Pediatrics, Mayo Clinic, Rochester, MN.
  • Myers SM; Geisinger Autism & Developmental Medicine Institute, Geisinger, Lewisburg, PA.
  • Weaver AL; Geisinger Commonwealth School of Medicine, Scranton, PA.
  • Nocton JJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
  • Voigt RG; Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI.
J Dev Behav Pediatr ; 45(1): e46-e53, 2024 01 01.
Article en En | MEDLINE | ID: mdl-38364086
ABSTRACT

OBJECTIVE:

Determine the risk of autoimmune disease in research-identified cases of autism spectrum disorder (ASD) compared with referents using a longitudinal, population-based birth cohort.

METHODS:

ASD incident cases were identified from a population-based birth cohort of 31,220 individuals. Inclusive ASD definition based on DSM-IV-TR autistic disorder, Asperger syndrome, and pervasive developmental disorder, not otherwise specified, was used to determine ASD cases. For each ASD case, 2 age- and sex-matched referents without ASD were identified. Diagnosis codes assigned between birth and December 2017 were electronically obtained. Individuals were classified as having an autoimmune disorder if they had at least 2 diagnosis codes more than 30 days apart. Cox proportional hazards models were fit to estimate the hazard ratio (HR) between ASD status and autoimmune disorder.

RESULTS:

Of 1014 ASD cases, 747 (73.7%) were male. Fifty ASD cases and 59 of the 12 matched referents were diagnosed with first autoimmune disorder at the median age of 14 and 17.1 years, respectively. ASD cases had increased risk of autoimmune disease compared with matched referents (HR 1.74; 95% confidence interval [CI], 1.21-2.52). The increased risk was statistically significant among male patients (HR 2.01; 95% CI, 1.26-3.21) but not among the smaller number of female subjects (HR 1.38; 95% CI, 0.76-2.50).

CONCLUSION:

This study provides evidence from a longitudinal, population-based birth cohort for co-occurrence of ASD and autoimmune disorders. Thus, children with ASD should be monitored for symptoms of autoimmune disease and appropriate workup initiated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos Generalizados del Desarrollo Infantil / Trastorno del Espectro Autista Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Dev Behav Pediatr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos Generalizados del Desarrollo Infantil / Trastorno del Espectro Autista Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Dev Behav Pediatr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos