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Synthesis of pyrazino[1,2-b]indazoles via cascade cyclization of indazole aldehydes with propargylic amines.
Wu, Zeng-Hui; Qu, Heng-Tong; Han, Ben-Jun; Yang, Jia-Xin; Chang, Xiang-Wei; Feng, Cheng-Tao.
Afiliación
  • Wu ZH; School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China. fengct@mail.ustc.edu.cn.
  • Qu HT; School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China. fengct@mail.ustc.edu.cn.
  • Han BJ; School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China. fengct@mail.ustc.edu.cn.
  • Yang JX; School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China. fengct@mail.ustc.edu.cn.
  • Chang XW; School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China. fengct@mail.ustc.edu.cn.
  • Feng CT; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, China.
Org Biomol Chem ; 22(11): 2226-2230, 2024 Mar 13.
Article en En | MEDLINE | ID: mdl-38363281
ABSTRACT
An efficient intermolecular annulation of indazole aldehydes with propargylic amines has been developed for the synthesis of pyrazinoindazoles under catalyst- and additive-free conditions. This straightforward methodology was found to feature a wide substrate scope, high atom economy and environmental advantages. The bioactivity results of these new pyrazino[1,2-b]indazoles showed that some of them exhibited significant antifungal activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido