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Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors.
Shakt, Gabrielle; Tsao, Noah L; Levin, Michael G; Walker, Venexia; Kember, Rachel L; Klarin, Derek; Tsao, Phil; Voight, Benjamin F; Scali, Salvatore T; Damrauer, Scott M.
Afiliación
  • Shakt G; Corporal Michael Crescenz VA Medical Center Philadelphia PA USA.
  • Tsao NL; Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
  • Levin MG; Corporal Michael Crescenz VA Medical Center Philadelphia PA USA.
  • Walker V; Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
  • Kember RL; Corporal Michael Crescenz VA Medical Center Philadelphia PA USA.
  • Klarin D; Department of Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
  • Tsao P; Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
  • Voight BF; Medical Research Council Integrative Epidemiology Unit University of Bristol Bristol United Kingdom.
  • Scali ST; Corporal Michael Crescenz VA Medical Center Philadelphia PA USA.
  • Damrauer SM; Department of Psychiatry, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
J Am Heart Assoc ; 13(4): e030233, 2024 Feb 20.
Article en En | MEDLINE | ID: mdl-38362853
ABSTRACT

BACKGROUND:

Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationship is lacking. METHODS AND

RESULTS:

Inverse variance weighted 2-sample Mendelian randomization was used to test the association the between genetic liability for MDD and genetic liability for PAD. Genetic liability for MDD was associated with increased genetic liability for PAD (odds ratio [OR], 1.17 [95% CI, 1.06-1.29]; P=2.6×10-3). Genetic liability for MDD was also associated with increased genetically determined lifetime smoking (ß=0.11 [95% CI, 0.078-0.14]; P=1.2×10-12), decreased alcohol intake (ß=-0.078 [95% CI, -0.15 to 0]; P=0.043), and increased body mass index (ß=0.10 [95% CI, 0.02-0.19]; P=1.8×10-2), which in turn were associated with genetic liability for PAD (smoking OR, 2.81 [95% CI, 2.28-3.47], P=9.8×10-22; alcohol OR, 0.77 [95% CI, 0.66-0.88]; P=1.8×10-4; body mass index OR, 1.61 [95% CI, 1.52-1.7]; P=1.3×10-57). Controlling for lifetime smoking index, alcohol intake, and body mass index with multivariable Mendelian randomization completely attenuated the association between genetic liability for MDD with genetic liability for PAD.

CONCLUSIONS:

This work provides evidence for a possible causal association between MDD and PAD that is dependent on intermediate risk factors, adding to the growing body of evidence suggesting that effective management and treatment of cardiovascular diseases may require a composite of physical and mental health interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Enfermedad Arterial Periférica Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Enfermedad Arterial Periférica Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido