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Mucosal melanoma of the head and neck: a retrospective analysis of 34 cases in Japan.
Tamura, Keiichi; Kumabe, Yohei; Kishimoto, Yo; Kitamura, Morimasa; Mizuta, Masanobu; Tamaki, Hisanobu; Honda, Keigo; Yamada, Koichiro; Tanaka, Shinzo; Kojima, Tsuyoshi; Asato, Ryo; Ushiro, Koji; Shinohara, Shogo; Takebayashi, Shinji; Maetani, Toshiki; Ichimaru, Kazuyuki; Kitani, Yoshiharu; Omori, Koichi.
Afiliación
  • Tamura K; Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kumabe Y; Department of Otolaryngology-Head & Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.
  • Kishimoto Y; Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kitamura M; Department of Head and Neck Surgery, Kanazawa Medical University, Ishikawa, Japan.
  • Mizuta M; Katsuragawa Mizuta ENT Clinic, Kyoto, Japan.
  • Tamaki H; Department of Otolaryngology-Head & Neck Surgery, Kurashiki Central Hospital, Okayama, Japan.
  • Honda K; Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yamada K; Department of Otolaryngology-Head & Neck Surgery, Kurashiki Central Hospital, Okayama, Japan.
  • Tanaka S; Department of Otolaryngology-Head & Neck Surgery, Uji-Tokushukai Medical Center, Kyoto, Japan.
  • Kojima T; Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Asato R; Department of Otolaryngology-Head & Neck Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Ushiro K; Department of Otolaryngology-Head & Neck Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Shinohara S; Department of Otolaryngology-Head & Neck Surgery, Kobe City Medical Center General Hospital, Hyogo, Japan.
  • Takebayashi S; Department of Otorhinolaryngology-Head & Neck Surgery, Shiga General Hospital, Shiga, Japan.
  • Maetani T; Department of Otolaryngology-Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka, Japan.
  • Ichimaru K; Department of Otolaryngology-Head & Neck Surgery, Kokura Memorial Hospital, Fukuoka, Japan.
  • Kitani Y; Department of Otorhinolaryngology-Head & Neck Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Omori K; Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Acta Otolaryngol ; 144(1): 82-89, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38362716
ABSTRACT

PURPOSE:

Mucosal melanoma of the head and neck (MMHN) is a rare condition. This study aimed to investigate oncological outcomes of surgical intervention in patients with MMHN. MATERIALS AND

METHODS:

The study included 34 patients with MMHN who underwent surgical resection as initial treatment at 10 institutions in Japan between July 2005 and June 2015.

Results:

The 5-year overall survival (OS), local control rate (LCR), disease-free survival (DFS), and disease-specific survival (DSS) rates were 48.7%, 53.4%, 32.4%, and 55.1%, respectively. Based on multivariate analysis, no independent prognostic factors for the 5-year OS and DSS were found. Based on univariate analysis, the 5-year LCR was worse in patients with lesions in the nasal cavity and paranasal sinuses than in the oral cavity and pharynx. However, no differences in oncological outcomes were identified in relation to primary sites, and postoperative radiotherapy (PORT) and adjuvant systemic therapy did not contribute to improvements in the 5-year OS.

CONCLUSIONS:

No independent prognostic factors for the 5-year OS or DSS were identified. Regional or distant recurrences are often identified, regardless of local control with surgical resection. Difficult control of MMHN with conventional therapeutic strategies, such as surgical intervention, PORT, and systemic therapy, has been suggested.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Neoplasias de Cabeza y Cuello / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Acta Otolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Neoplasias de Cabeza y Cuello / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Acta Otolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido