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Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma.
Riobello, Cristina; Sánchez-Fernández, Paula; Córdoba, María Camila Cubides; González-Gutiérrez, Maripaz; Vivanco, Blanca; Cabal, Virginia N; Fernández, Laura Suárez; García-Marín, Rocío; Codina-Martínez, Helena; Lorenzo-Guerra, Sara Lucila; López, Fernando; Hermsen, Mario A; Llorente, José Luis.
Afiliación
  • Riobello C; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • Sánchez-Fernández P; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Córdoba MCC; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • González-Gutiérrez M; Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Vivanco B; Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Cabal VN; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • Fernández LS; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • García-Marín R; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • Codina-Martínez H; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • Lorenzo-Guerra SL; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • López F; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Hermsen MA; Department of Head and Neck Cancer, Health Research Institute of the Principality of Asturias, Oviedo, Spain.
  • Llorente JL; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Head Neck ; 46(8): 2010-2019, 2024 08.
Article en En | MEDLINE | ID: mdl-38362701
ABSTRACT

BACKGROUND:

Recurrent intestinal-type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.

METHODS:

Twelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next-generation sequencing.

RESULTS:

Histological differences between primary and recurrent tumor pairs were observed in five cases. Frequent mutations included TP53, APC, TSC2, ATM, EPHA2, BRCA2, LRP1B, KRAS, and KMT2B. There was 86% concordance of somatic mutations between the tumor pairs, while four cases carried additional mutations in the recurrence.

CONCLUSIONS:

We found all cases to be clonal recurrences and not second primary tumors. Moreover, tumor pairs showed a remarkable genomic stability, suggesting that personalized treatment of a recurrence may be based on actionable molecular genetic targets observed in the primary tumor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Adenocarcinoma / Secuenciación de Nucleótidos de Alto Rendimiento / Recurrencia Local de Neoplasia Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Adenocarcinoma / Secuenciación de Nucleótidos de Alto Rendimiento / Recurrencia Local de Neoplasia Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos