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Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35.
Cai, Jin; Zhou, Xueming; Wang, Bin; Zhang, Xuelong; Luo, Mengyao; Huang, Longtao; Wang, Ruoxi; Chen, Yonghao; Li, Xiaoyang; Luo, Youping; Chen, Guangying; Cao, Fei; Huang, Guolei; Zheng, Caijuan.
Afiliación
  • Cai J; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Zhou X; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Wang B; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Zhang X; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Luo M; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Huang L; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Wang R; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Chen Y; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Li X; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Luo Y; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Chen G; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Cao F; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
  • Huang G; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • Zheng C; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
Front Microbiol ; 15: 1342843, 2024.
Article en En | MEDLINE | ID: mdl-38362503
ABSTRACT
Six new polyketides, which includes three new lactones (talarotones A-C) (1-3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8-20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1-7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 µM. Compounds 7, 10-12, and 14-18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50-200 µg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 µg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza