Your browser doesn't support javascript.
loading
The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects.
Lu, Bowen; Lim, Jing Ming; Yu, Boyue; Song, Siyuan; Neeli, Praveen; Sobhani, Navid; K, Pavithra; Bonam, Srinivasa Reddy; Kurapati, Rajendra; Zheng, Junnian; Chai, Dafei.
Afiliación
  • Lu B; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Lim JM; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Yu B; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Song S; Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
  • Neeli P; Department of Environmental Science, Policy, and Management, University of California at Berkeley, Berkeley, CA, United States.
  • Sobhani N; Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States.
  • K P; Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
  • Bonam SR; Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
  • Kurapati R; School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, India.
  • Zheng J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
  • Chai D; School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, India.
Front Immunol ; 15: 1332939, 2024.
Article en En | MEDLINE | ID: mdl-38361919
ABSTRACT
Vaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks and others. These limitations restrict their widespread use, especially in the face of an increasingly diverse range of diseases. With the ongoing advancements in genetic engineering vaccines, DNA vaccines have emerged as a highly promising approach in the treatment of both genetic diseases and acquired diseases. While several DNA vaccines have demonstrated substantial success in animal models of diseases, certain challenges need to be addressed before application in human subjects. The primary obstacle lies in the absence of an optimal delivery system, which significantly hampers the immunogenicity of DNA vaccines. We conduct a comprehensive analysis of the current status and limitations of DNA vaccines by focusing on both viral and non-viral DNA delivery systems, as they play crucial roles in the exploration of novel DNA vaccines. We provide an evaluation of their strengths and weaknesses based on our critical assessment. Additionally, the review summarizes the most recent advancements and breakthroughs in pre-clinical and clinical studies, highlighting the need for further clinical trials in this rapidly evolving field.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas de ADN Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas de ADN Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza